Acute hypersensitivity reactions and a flu-like syndrome developed during infusion. May develop immunogenicity. May impair immune function (patients with cutaneous T-cell lymphoma are predisposed to cutaneous infection). Associated with delayed-onset vascular leak syndrome (should be used with caution in preexisting cardiovascular disease and/or low serum albumin concentrations). Visual disturbances may occur. Caution in patients >65 years (higher incidence and greater severity of anorexia, hypotension, anemia, confusion, rash, nausea, and/or vomiting observed).