Dicyclomine
- Atc Codes:A03AA07
- CAS Codes:67-92-5#77-19-0
- PHARMGKB ID:67-92-5#77-19-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
UK: Merbentyl.
North America
Canada: Bentylol, Dicyclomine, Formulex, Lomine, Protylol; USA: Bentyl, Dicyclomine.
Latin America
Argentina: Babypasmil; Mexico: Clominal, Sediclon.
Asia
Japan: Magesan P, Resporimin.
Drug combinations
Dicyclomine, Diazepam, Lidocaine, and Simethicone
Dicyclomine, Aluminum Glycinate, Diazepam, Lidocaine, Magnesium Oxide, and Simethicone
Chemistry
Dicyclomine Hydrochloride: C~19~H~35~NO~2~ HCl. Mw: 345.95. (1) [Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride; (2) 2-(Diethylamino)ethyl [bicyclohexyl]-1-carboxylate hydrochloride. CAS-67-92-5; CAS-77-19-0 (dicyclomine).
Pharmacologic Category
Anticholinergic Agents; Antimuscarinics/Antispasmodics. (ATC-Code: A03AA07).
Mechanism of action
Blocks action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands and CNS.
Therapeutic use
Treatment of functional bowel/irritable bowel syndrome.
Pregnancy and lactiation implications
Teratogenic effects not observed in animal studies. Contraindicated during lactation.
Unlabeled use
Urinary incontinence.
Contraindications
Hypersensitivity to dicyclomine or any component of the formulation. Obstructive diseases of the GI tract. Severe ulcerative colitis. Reflux esophagitis. Unstable cardiovascular status in acute hemorrhage. Obstructive uropathy. Narrow-angle glaucoma. Myasthenia gravis. Breast-feeding. Infants <6 months of age.
Warnings and precautions
May cause drowsiness and/or blurred vision. Diarrhea (may be a sign of incomplete intestinal obstruction). Heat prostration (use caution in hot weather and/or exercise). Psychosis (in sensitivity to anticholinergic effects or at excessive dosages). Caution in cardiovascular disease (e.g. coronary artery disease, tachyarrhythmias, heart failure, hypertension), hepatic impairment, hiatal hernia, hyperthyroidism, autonomic neuropathy, prostatic hyperplasia, renal impairment, ulcerative colitis or the elderly. Serious respiratory reactions, central nervous symptoms, and deaths reported in children (contraindicated in infants <6 months of age).