Allergic contact dermatitis can occur (failure to heal). Prolonged treatment with corticosteroids associated with the development of Kaposi’s sarcoma (case reports). Adverse systemic effects including Cushing’s syndrome, hyperglycemia, glycosuria, fluid and electrolyte changes, and reversible HPA-axis suppression (particularly in younger children) may occur when used on large surface areas, for prolonged periods, or with an occlusive dressing. Infants and children may be more susceptible to adverse systemic effects. Children are at greater risk of glucocorticoid insufficiency during and/or after withdrawal of treatment. Intracranial hypertension has occurred in children. Striae reported in children treated inappropriately with topical corticosteroids. Chronic topical corticosteroid therapy may interfere with growth and development in children. Prolonged use of topical corticosteroids may cause atrophy of the epidermis and subcutaneous tissue, mostly in intertriginous (e.g. axilla, groin), flexor, and facial areas. Irritation might occur. Do not use occlusive dressings on weeping or exudative lesions or in primary skin infection. Infection might develop.