Corticosteroids inhibit the inflammatory response including edema, capillary dilation, leukocyte migration, and scar formation. Difluprednate penetrates cells readily to induce the production of lipocortins. These proteins modulate the activity of prostaglandins and leukotrienes.
Therapeutic use
Treatment of inflammation and pain following ocular surgery.
Pregnancy and lactiation implications
Should be used with caution in pregnant or lactating women.
Unlabeled use
Contraindications
Active viral (including herpes simplex keratitis, vaccinia, varicella) infections of the cornea or conjunctiva, fungal infection of ocular structures, or mycobacterial ocular infections.
Warnings and precautions
Steroids may mask infection or enhance existing ocular infection. Prolonged use may result in glaucoma and injury to the optic nerve, as well as visual defects in acuity and field of vision. Posterior subcapsular cataracts may form after long-term use. Perforation may occur with topical steroids in diseases which thin the cornea or sclera. May delay healing after cataract surgery. Contains sorbic acid which may be adsorbed by contact lenses.