Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Prepidil, Propess, Prostin E2; Belgium: Prepidil, Prostin E2; Bulgaria: Prepidil, Prostin E2; Cyprus: Prepidil, Prostin E2; Czech Republic: Prepidil, Prostin E2; Denmark: Minprostin, Propess; Estonia: Prostenoon; France: Prepidil, Propess, Prostine E2; Germany: Cerviprost, Dinoproston, Minprostin E2, Prepidil, Propess; Greece: Propess, Prostin E2; Hungary: Prepidil, Prostin E2; Ireland: Prostin E2; Italy: Prepidil, Propess; Latvia: Prostenoon; Luxembourg: Prepidil, Prostin E2; Malta: Propess, Prostin E2; Netherlands: Prepidil, Propess, Prostin E2; Poland: Prepidil, Prostin E2; Portugal: Propess, Prostin E2; Romania: Propess; Slovakia: Prepidil, Prostin E2; Spain: Prepidil, Propess, Prostaglandina E2; Sweden: Minprostin, Propess; UK: Propess, Prostin E2.

North America

Canada: Cervidil, Prepidil, Prostin E2; USA: Cervidil, Prepidil, Prostin E2.

Latin America

Argentina: Prolisina E2, Propess; Mexico: Propess.


Japan: Prostaglandin E2, Prostarmon E.

Drug combinations


Dinoprostone: C~20~H~32~O~5~. Mw: 352.47. (1) Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11α,13E,15S)-; (2)(E,Z)-(1R,2R,3R)-7-[3-Hydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic acid; (3) Prostaglandin E~2~. CAS-363-24-6 (1971).

Pharmacologic Category

Oxytocics. Abortifacient. Prostaglandin. (ATC-Code: G02AD02).

Mechanism of action

A synthetic prostaglandin E~2~ abortifacient that stimulates uterine smooth muscle and also produces cervical dilation and softening.

Therapeutic use

Termination of intrauterine pregnancy during the second trimester. Labor induction (cervical «ripening»). Evacuation of uterine contents in cases of missed abortion, intrauterine fetal death up to 28 weeks of gestational age, or nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Pregnancy and lactiation implications

Animal studies indicate that prostaglandins may be teratogenic. Vaginal suppositories should not be used in a woman at term pregnancy. Endogenous PGE~2~ can be detected in breast milk. High levels have been associated with diarrhea in nursing infants.

Unlabeled use

Has been used in the management of postpartum hemorrhage.


Hypersensitivity to prostaglandins or any component of the formulation. Fetal distress (suspicion or clinical evidence unless delivery is imminent). Unexplained vaginal bleeding during pregnancy. Strong suspicion of marked cephalopelvic disproportion. Patients in whom oxytocic drugs are contraindicated or when prolonged contraction of the uterus may be detrimental to fetal safety or uterine integrity (including previous cesarean section or major uterine surgery). >6 previous term pregnancies. Patients already receiving oxytocic drugs. Hyperactive or hypotonic uterine patterns. When vaginal delivery is not indicated. Obstetrical emergencies when surgical intervention would be favorable. Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.

Warnings and precautions

Use caution with ruptured membranes, nonvertex or nonsingleton pregnancy, previous uterine hypertony, glaucoma, or history of asthma. Transient pyrexia and decreased blood pressure may occur (suppository). Use caution with history of asthma, hypotension or hypertension, cardiovascular, renal/hepatic disease, anemia, jaundice, diabetes, epilepsy, compromised uteri, cervicitis, endocervical infections or acute vaginitis. Do not use for cervical ripening or other indications in term pregnancy.



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