Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Domperidon, Motilium, Oroperidys; Belgium: Docdomperi, Domperidon, Domperidone, Domperitop, Motilium, Oroperidys, Zilium; Bulgaria: Costi, Motilium; Cyprus: Costi, Motilium; Czech Republic: Motilium, Oroperidys; Denmark: Domperidon, Motilium; Estonia: Domperidon, Oroperidys; Finland: Oroperidys; France: Biperidys, Domperidone, Motilium, Oroperidys, Peridys; Germany: Domidon, Domperidon, Motilium, Oroperidys; Greece: Cilroton, Oroperidys; Hungary: Domperidon, Motilium, Oroperidys; Ireland: Domerid, Domperidone, Motilium; Italy: Dalia, Domperidone, Faintop, Gerdi, Lauter, Motilium, Peridon, Permotil, Riges, Stalcare; Latvia: Domperidon, Motilium, Oroperidys; Lithuania: Domperidon, Domstal, Motilium, Oroperidys; Luxembourg: Motilium; Malta: Costi, Digestivo Giuliani, Domperidon, Domperidone, Motilium; Netherlands: Domperidon, Motilium; Poland: Motilium, Oroperidys; Portugal: Cinet, Domperidona, Mogasinte, Motilium, Nausidone, Oroperidys, Remotil; Romania: Motilium, Oroperidys; Slovakia: Costi, Motilium; Slovenia: Tametil; Spain: Domperidona, Motilium; Sweden: Oroperidys; UK: Domperidone, Motilium.

North America

Canada: Domperidone.

Latin America

Argentina: Ecuamon, Motilium, Peridon; Brazil: Motilium, Peridal; Mexico: Biolix, Emiken, Motilium, Seronex.


Japan: Arcelenan, Cobaperidon, Dalic, Domperidone, Domperin, Donpenema, Forimezin, Hadodolin, Jackmar, Mionazelin, Monlobia, Nasirobin, Nausea, Nauzart, Nauzelin, Perizelin, Peroric, Selovase.

Drug combinations

Domperidone and Cinnarizine

Domperidone and Ranitidine

Domperidone and Simethicone

Domperidone, Alprazolam, and Simethicone

Domperidone, Bromazepam, and Simethicone

Domperidone, Dehydrocholic Acid, and Simethicone

Domperidone, Amylase, Lipase, Protease, and Simethicone


Domperidone: C~22~H~24~ClN~5~O~2~. Mw: 425.91. (1) 2H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-; (2) 5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone. CAS-57808-66-9 (1976).

Pharmacologic Category

Prokinetic Agents. Dopamine Antagonist. (ATC-Code: A03FA03).

Mechanism of action

Has peripheral dopamine receptor blocking properties. Increases esophageal peristalsis and lower esophageal sphincter pressure, gastric motility and peristalsis, and enhances gastroduodenal coordination, therefore facilitating gastric emptying and decreasing small bowel transit time.

Therapeutic use

Symptomatic management of upper GI motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis. Prevention of GI symptoms associated with use of dopamine-agonist anti-Parkinson agents.

Pregnancy and lactiation implications

Use only when benefit outweighs potential risk to the fetus. Caution when administered to a breast-feeding woman (use not recommended by the manufacturer).

Unlabeled use


Hypersensitivity to domperidone or any component of the formulation. Patients with GI hemorrhage, mechanical obstruction, or perforation. Prolactin-releasing pituitary tumor.

Warnings and precautions

QTc prolongation, life-threatening tachyarrhythmias, and cardiac arrest reported and may be precipitated in hypokalemic patients. May increase prolactin levels (dose-dependent response). Use caution when administering to patients with personal or family history of breast cancer. Use with caution in hepatic impairment. Use with caution in patients concomitantly taking MAO inhibitors.



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