May cause anticholinergic effects (use with caution in decreased GI motility, urinary retention, BPH, xerostomia, or visual problems). Esophageal dysmotility/aspiration may occur (use with caution in patients at risk of pneumonia (e.g. Alzheimer’s disease)). May cause extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia. Risk of dystonia (with increased doses, use of conventional antipsychotics, in males and younger patients). May cause orthostatic hypotension (use with caution in patients at risk of this effect or in those who would not tolerate transient hypotensive episodes (cerebrovascular disease, cardiovascular disease, hypovolemia, or concurrent medication use which may predispose to hypotension/bradycardia)). May be associated with pigmentary retinopathy. May be sedating. Impaired core body temperature regulation may occur (caution with strenuous exercise, heat exposure, dehydration, and concomitant medication possessing anticholinergic effects). Use with caution in narrow-angle glaucoma, myasthenia gravis (these conditions may be exacerbated by cholinergic blockade). Use with caution in breast cancer or other prolactin-dependent tumors (may elevate prolactin levels). Use with caution in patients at risk of seizures, including those with history of seizures, head trauma, brain damage, alcoholism, or concurrent therapy with medications which may lower seizure threshold. May mask toxicity of other drugs or conditions (e.g. intestinal obstruction, Reye’s syndrome, brain tumor) due to antiemetic effects. QT interval prolongation and serious, sometimes fatal arrhythmias (torsades de pointes, ventricular arrhythmias, cardiac arrest) have occurred (use with extreme caution in patients with risk factors for prolonged QT syndrome). Hypotension may occur. May cause CNS depression. Neuroleptic malignant syndrome (altered consciousness, muscular rigidity, autonomic instability) has occurred. Certain forms of conduction anesthesia (e.g. spinal anesthesia, peridural anesthesia) can alter respiration by blocking intercostal nerves and can cause peripheral vasodilation and hypotension. Droperidol may decrease pulmonary arterial pressure and interfere with interpretation of hemodynamic measurements. Use with caution in diagnosed or suspected pheochromocytoma (severe hypertension and tachycardia may occur). Use with caution in the elderly. Use with caution in hepatic or renal impairment.