Dyphylline
- Atc Codes:R03DA01
- CAS Codes:479-18-5
- PHARMGKB ID:479-18-5
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Lufyllin.
Drug combinations
Dyphylline and Guaifenesin
Chemistry
Dyphylline: C~10~H~14~N~4~O~4~. Mw: 254.24. (1) 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-, (±)-; (2)(±)-7-(2,3-Dihydroxypropyl)theophylline. CAS-479-18-5.
Pharmacologic Category
Bronchodilators; Xanthine Derivatives; Theophyllines. (ATC-Code: R03DA01).
Mechanism of action
Causes bronchodilatation through phosphodiesterase inhibition, which increases concentrations of cAMP and produces relaxation of bronchial smooth muscle.
Therapeutic use
Bronchodilator in reversible airway obstruction due to asthma, chronic bronchitis, or emphysema.
Pregnancy and lactiation implications
Reproduction studies not conducted. Use with caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to dyphylline, xanthine compounds, or any component of the formulation. Status asthmaticus.
Warnings and precautions
Use with caution in cardiovascular disease, including acute myocardial injury, hypertension, and heart failure. Use with caution in hyperthyroidism, peptic ulcer disease, or renal impairment. Xanthine derivatives, including theophylline, are not indicated for the management of status asthmaticus.