Edetate Calcium Disodium

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


France: Calcium Edetate de Sodium; Greece: Ledclair; Ireland: Ledclair.

North America

USA: Calcium Disodium Versenate.


Japan: Bleian.

Drug combinations

Edetate Calcium Disodium and Metabisulfite

Edetate Calcium Disodium, Boric Acid, Hydroxypropyl Methylcellulose, Sodium Chloride, and Sodium Hyaluronate

Edetate Calcium Disodium, Biguanide, Citric Acid, Hydroxypropyl Methylcellulose, Sodium Chloride, and Sodium Citrate

Other Edetate Calcium Disodium combinations: Ginkgo biloba; Papaverine


Edetate Calcium Disodium: C~10~H~12~CaN~2~Na~2~O~8~ xH~2~O. Mw: 374.27 (anhydrous). (1) Calciate (2-), [[N,N’-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N’,O,O’,O^N^,O^N’^]-, disodium, hydrate, (OC-6-21)-; (2) Disodium[(ethylenedinitrilo)tetraacetato]calciate(2-) hydrate. CAS-23411-34-9; CAS-62-33-9 (anhydrous); CAS-60-00-4 (edetic acid)(1962).

Pharmacologic Category

Heavy Metal Antagonists; Chelating Agent. Antidotes. (ATC-Code: V03AB03; S01XA05).

Mechanism of action

Edetate calcium disodium (calcium EDTA) is a heavy metal antagonist which chelates lead, zinc, and other heavy metals. Calcium is displaced by divalent and trivalent heavy metals, forming a nonionizing soluble complex which is excreted in urine.

Therapeutic use

Parenterally administered calcium EDTA is used for the reduction of blood and mobile depot lead in the treatment of acute and chronic lead poisoning and lead encephalopathy. Useful in poisonings caused by alkyl lead compounds (e.g. tetraethyl lead).

Pregnancy and lactiation implications

Adverse events observed in some animal reproduction studies. Chelation therapy during pregnancy is for maternal benefit only and should be limited to the treatment of severe, symptomatic lead poisoning. Use with caution during lactation.

Unlabeled use

Possibly useful in poisoning by zinc, manganese, and certain heavy radioisotopes.


Hypersensitivity to edetate calcium disodium or any component of the formulation. Severe renal disease or anuria. Hepatitis.

Warnings and precautions

Risk of nephrotoxicity (renal tubular acidosis and fatal nephrosis may occur), especially with high doses. ECG changes may occur during therapy. Anuria, increasing proteinuria, or hematuria may also occur. Use with extreme caution in lead encephalopathy or cerebral edema (I.V. infusion associated with lethal increase in intracranial pressure). Use with caution in renal impairment. Edetate calcium disodium can produce serious and sometimes fatal toxic effects.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Email: genomicmedicine@wagem.org
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart