Edrophonium
- Atc Codes:N07AA
- CAS Codes:116-38-1#312-48-1
- PHARMGKB ID:116-38-1#312-48-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Spain: Anticude; UK: Edrophonium.
North America
Canada: Tensilon; USA: Edrophonium, Enlon, Tensilon.
Asia
Japan: Antirex.
Drug combinations
Edrophonium and Atropine
Chemistry
Edrophonium Chloride: C~10~H~16~ClNO. Mw: 201.69. (1) Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride; (2) Ethyl(m-hydroxyphenyl)dimethylammonium chloride. CAS-116-38-1; CAS-312-48-1 (edrophonium).
Pharmacologic Category
Diagnostic Agents; Myasthenia Gravis; Cholinergic Agonist. Antidotes. (ATC-Code: N07AA).
Mechanism of action
A synthetic quaternary ammonium parasympathomimetic (cholinergic) agent, used to diagnose myasthenia gravis. Inhibits destruction of acetylcholine by acetylcholinesterase, facilitating transmission of impulses across myoneural junction and increasing cholinergic responses such as miosis, increased tonus of intestinal and skeletal muscles, bronchial and ureteral constriction, bradycardia, and increased salivary and sweat gland secretions.
Therapeutic use
Differential diagnosis of myasthenia gravis. May also be used to differentiate cholinergic crisis from myasthenic crisis. Reversal of nondepolarizing neuromuscular blockers. Respiratory depression caused by curare overdose.
Pregnancy and lactiation implications
Anticholinesterase drugs may cause uterine irritability and induce premature labor when given I.V. to pregnant women near term. Use of edrophonium in pregnant women requires possible benefits to be weighed against potential risks. Safe use of edrophonium in nursing women not established.
Unlabeled use
Contraindications
Hypersensitivity to edrophonium, sulfites, or any component of the formulation. GI or GU obstruction.
Warnings and precautions
Overdosage can cause potentially fatal cholinergic crisis. Use with caution in cardiac arrhythmias (e.g. bradyarrhythmias). Should be used cautiously in bronchial asthma and in patients receiving a cardiac glycoside (may enhance AV block). Avoid use in myasthenia gravis (may exacerbate muscular weakness). Products may contain sodium sulfite (may cause allergic-type reactions, including anaphylaxis and life-threatening or less severe asthmatic episodes, in certain susceptible individuals.). Edrophonium is contraindicated in mechanical obstruction of the intestinal or urinary tracts.