Epinastine
- Atc Codes:R06AX24#S01GX10
- CAS Codes:80012-43-7#80012-44-8
- PHARMGKB ID:80012-43-7#80012-44-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Relestat; Belgium: Relestat; Czech Republic: Purivist; Finland: Relestat; France: Purivist; Germany: Relestat; Greece: Relestat; Hungary: Relestat; Ireland: Relestat; Italy: Relestat; Netherlands: Relestat; Poland: Relestat; Portugal: Relestat; Slovakia: Purivist; Spain: Relestat; Sweden: Relestat; UK: Relestat.
North America
USA: Elestat.
Latin America
Argentina: Alket-Poen, Epioftal, Flurinol, Relestat; Brazil: Talerc; Mexico: Flurinol.
Asia
Japan: Alegain, Alenapion, Aleroff, Alesion, Alesiotec, Allernothin, Alpeed, Aplatin, Asmot, Azusaleon, Bellgfolm, Elpinan, Epinastine, Epinazion, Helvottz, Medejion, Pinasion, Timkent, Yupitel.
Drug combinations
Chemistry
Epinastine: C~16~H~15~N~3~. Mw: 249.31. 3-Amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine. CAS-80012-43-7; CAS-80012-44-8 (hydrochloride).
Pharmacologic Category
EENT Preparations; Antiallergic Agents. Ophthalmic Antihistamine H~1~ Blocker. (ATC-Code: R06AX24; S01GX10).
Mechanism of action
Relatively selective histamine H~1~-receptor antagonist with mast-cell stabilizing properties. Inhibits release of histamine from the mast cell.
Therapeutic use
Prevention of ocular itching associated with allergic conjunctivitis.
Pregnancy and lactiation implications
Teratogenic effects not observed in animal studies. There are no adequate, well-controlled studies in pregnant women. Use with caution during lactation.
Unlabeled use
Contraindications
Hypersensitivity to epinastine or any component of the formulation.
Warnings and precautions
Risk of bacterial keratitis with contamination of multiple-dose ophthalmic solutions. Contains benzalkonium chloride, which may be absorbed by contact lenses. For topical ophthalmic use only. Not for treatment of contact lens irritation.