Drugs that act on the angiotensin system can cause injury and death to the developing fetus when used in the 2^nd^ and 3^rd^ trimesters. Symptomatic hypotension, including orthostatic hypotension, may occur (increased risk in volume or salt depletion secondary to salt restriction, prolonged diuretic therapy, or dialysis). Facial edema has occurred. Extreme caution in history of angioedema associated with or unrelated to ACE or angiotensin II receptor antagonist therapy. Use with caution in hepatic impairment. Hyperkalemia may occur (risk factors include renal dysfunction, diabetes mellitus, concomitant use of potassium-sparing diuretics, potassium supplements and/or potassium-containing salts). Renal function deterioration and/or increases in serum creatinine (deterioration may result in oliguria, acute renal failure, and progressive azotemia). Use with caution in unstented unilateral/bilateral renal artery stenosis. Use with pre-existing renal insufficiency and severe renal impairment. Use with caution in significant aortic/mitral stenosis. Avoid use or reduce dose in volume-depleted patients.