Benzodiazepines have been associated with anterograde amnesia. May cause CNS depression. Use of hypnotic/sedative agents for sleep has been associated with hypersensitivity reactions including anaphylaxis as well as angioedema. Paradoxical reactions, including hyperactive or aggressive behavior, reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Increased risk for sleep-related activities. Use caution in depression, particularly if suicidal risk may be present, in history of drug abuse or acute alcoholism (potential for drug dependency exists), in hepatic or renal impairment, in impaired gag reflux, and in respiratory disease. Use with caution in patients receiving other CNS depressants or psychoactive medication (effects with other sedative drugs or ethanol may be potentiated). High potential for CYP-mediated interactions. Use with caution in debilitated patients, and in the elderly (risk of falls and traumatic injury). Use with extreme caution in patients at risk of falls. Does not have analgesic, antidepressant, or antipsychotic properties. Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose. Flumazenil may cause withdrawal in patients receiving long-term benzodiazepine therapy.