Ethacrynic Acid
- Atc Codes:C03CC01
- CAS Codes:58-54-8
- PHARMGKB ID:58-54-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Hungary: Uregyt.
North America
Canada: Edecrin; USA: Edecrin.
Drug combinations
Chemistry
Ethacrynic Acid: C~13~H~12~Cl~2~O~4~. Mw: 303.14. Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-. CAS-58-54-8 (1963).
Pharmacologic Category
Diuretics; Loop Diuretics. (ATC-Code: C03CC01).
Mechanism of action
Inhibits reabsorption of sodium and chloride in the ascending loop of Henle and distal renal tubule, interfering with the chloride-binding cotransport system, thus causing increased excretion of water, sodium, chloride, magnesium, and calcium.
Therapeutic use
Management of edema associated with CHF. Hepatic cirrhosis or renal disease. Short-term management of ascites due to malignancy, idiopathic edema, and lymphedema.
Pregnancy and lactiation implications
Generally, use of diuretics during pregnancy is to be avoided due to risk of decreased placental perfusion. Contraindicated during lactation.
Unlabeled use
Contraindications
Hypersensitivity to ethacrynic acid or any component of the formulation. Anuria. History of severe watery diarrhea caused by this product. Infants.
Warnings and precautions
Excess amounts can lead to profound diuresis with fluid and electrolyte loss. Hypersensitivity reactions (rarely). Nephrotoxicity might occur. Associated with ototoxicity. Acid/base imbalances should be avoided (might lead to hepatic encephalopathy). Co-administration of antihypertensives may increase the risk of hypotension. Avoid use in renal impairment (CrCl <10 mL/minute).