Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

Austria: Adenuric; Bulgaria: Adenuric; Czech Republic: Adenuric; Estonia: Adenuric; Finland: Adenuric; France: Adenuric; Germany: Adenuric; Greece: Adenuric; Ireland: Adenuric; Latvia: Adenuric; Lithuania: Adenuric; Luxembourg: Adenuric; Malta: Adenuric; Netherlands: Adenuric; Poland: Adenuric; Portugal: Adenuric; Romania: Adenuric; Slovakia: Adenuric; Slovenia: Adenuric; Sweden: Adenuric; UK: Adenuric.

North America

Canada: Uloric; USA: Uloric.

Drug combinations


Febuxostat: C~16~H~16~N~2~O~3~S. Mw: 316.37. (1) 2-[3-Cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid; (2) 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid. CAS-144060-53-7.

Pharmacologic Category

Antigout Agents; Xanthine Oxidase Inhibitor. (ATC-Code: M04AA03).

Mechanism of action

Selectively inhibits xanthine oxidase (XO/XDH), the enzyme responsible for the conversion of hypoxanthine to xanthine to uric acid, thereby decreasing uric acid. At therapeutic concentration does not inhibit other enzymes involved in purine and pyrimidine synthesis.

Therapeutic use

Chronic management of hyperuricemia in patients with gout.

Pregnancy and lactiation implications

Use during pregnancy only if potential benefit to mother outweighs potential risk to fetus. Not recommended during lactation.

Unlabeled use


Concurrent use with azathioprine, mercaptopurine, or theophylline.

Warnings and precautions

Thromboembolic events such as MI, stroke and cardiovascular deaths were reported at a slightly increased rate than allopurinol in controlled studies. Hyperuricemia.



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