Felodipine
- Atc Codes:C08CA02
- CAS Codes:72509-76-3#86189-69-7
- PHARMGKB ID:72509-76-3#86189-69-7
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Felodipin, Munobal, Plendil; Belgium: Felodipine, Plendil, Renedil; Bulgaria: Auronal, Felicipin, Felodipine, FeloHEXAL, Plendil, Presid; Cyprus: Enfelo, Felodipine, Plendil; Czech Republic: Auronal, Felocor, Felodipin, Plendil, Presid; Denmark: Felodin, Felodipin, Plendil, Plendur; Estonia: Felodipin, Plendil, Presid; Finland: Felodipin, Hydac, Plendil; France: Felodipine, Flodil L.P.; Germany: Felobeta, Felocor, Felodipin, Felogamma, Felopharm, Felostap, Modip, Munobal, Plendil; Greece: Felodipine, Plendil; Hungary: Felodipine, Plendil, Presid; Ireland: Felodipine, Plendil; Italy: Feloday, Felodipina, Plendil, Prevex; Latvia: Felodipin, Plendil, Presid; Lithuania: Felodipin, Plendil, Presid; Luxembourg: Plendil, Renedil; Malta: Plendil; Netherlands: Felodipine, Plendil; Poland: Auronal, Felodipin, Felowin, Fepress, Plendil; Portugal: Felodipina, Plendil, Preslow; Romania: Auronal, Felodipin, Mivara, Plendil, Presid, Sistar; Slovakia: Auronal, Felodipin, Felocor, Plendil, Presid; Spain: Felodipino, Plendil; Sweden: Felodipin, Plendil; UK: Cardioplen XL, Felotens XL, Plendil, Vascalpha.
North America
Canada: Plendil, Renedil; USA: Felodipine.
Latin America
Argentina: Munobal, Plendil; Brazil: Splendil; Mexico: Dylofen, Eutens, Fedin, Hofodilan, Munobal, Nafapin, Nafpin, Plendil.
Asia
Japan: Catrazil, Munobal, Splendil.
Drug combinations
Felodipine and Enalapril
Felodipine and Metoprolol
Felodipine and Ramipril
Chemistry
Felodipine: C~18~H~19~Cl~2~NO~4~. Mw: 384.25. (1) 3,5-Pyridinedicarboxylic acid 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester, (±)-; (2)(±)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate. CAS-72509-76-3; CAS-86189-69-7 (1985).
Pharmacologic Category
Calcium-Channel Blocking Agents; Dihydropyridines. (ATC-Code: C08CA02).
Mechanism of action
Inhibits calcium ions from entering the «slow channels» or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation. Increases myocardial oxygen delivery in vasospastic angina.
Therapeutic use
Treatment of hypertension.
Pregnancy and lactiation implications
Potentially, calcium channel blockers may prolong labor. There are no adequate, well-controlled studies in pregnant women. Use not recommended during lactation.
Unlabeled use
Pediatric hypertension.
Contraindications
Hypersensitivity to felodipine, any component of the formulation, or other calcium channel blockers.
Warnings and precautions
Possible hypotension and/or syncope resulting in reflex tachycardia and precipitation of angina pectoris in susceptible patients. Peripheral edema is common. May reduce coronary perfusion resulting in ischemia (use with extreme caution in severe aortic stenosis). Use with caution in heart failure, or compromised ventricular function (particularly when used in combination with a β-adrenergic blocker). Use with caution in hepatic impairment (felodipine clearance may be decreased), or in hypertrophic cardiomyopathy and outflow tract obstruction (reduction in afterload may worsen symptoms).