Fenoldopam
- Atc Codes:C01CA19
- CAS Codes:67227-57-0#67227-56-9
- PHARMGKB ID:67227-57-0#67227-56-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Italy: Corlopam.
North America
Canada: Corlopam; USA: Corlopam, Fenoldopam.
Drug combinations
Chemistry
Fenoldopam Mesylate: C~16~H~16~ClNO~3~ CH~4~SO~3~. Mw: 401.86. (1) 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, methanesulfonate; (2) 6-Chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate. CAS-67227-57-0;CAS-67227-56-9 (fenoldopam)(1984).
Pharmacologic Category
Hypotensive Agents; Direct Vasodilators, Dopamine Agonist. (ATC-Code: C01CA19).
Mechanism of action
A selective postsynaptic dopamine agonist (D~1~-receptors) which exerts hypotensive effects by decreasing peripheral vasculature resistance with increased renal blood flow, diuresis, and natriuresis. Six times as potent as dopamine in producing renal vasodilitation. Has minimal adrenergic effects.
Therapeutic use
Treatment of severe hypertension (up to 48 hours in adults), including in renal compromise. Short-term (up to 4 hours) blood pressure reduction in pediatric patients.
Pregnancy and lactiation implications
Fetal harm not observed in animal studies. Use during pregnancy only if clearly needed.
Unlabeled use
Contraindications
Hypersensitivity of fenoldopam or any component of the formulation.
Warnings and precautions
Tachycardia can occur (dose-related). Use with caution in angina (can increase myocardial oxygen demand with tachycardia), in open-angle glaucoma or intraocular hypertension, or in increased intracranial pressure. Contains sulfites (may cause allergic reaction in susceptible individuals). For continuous infusion only. Hypotension can occur.