Ferrous Sulfate

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Ferro-Gradumet, Tardyferon; Belgium: Fero-Gradumet; Bulgaria: Ferro-Gradumet; Cyprus: Microfer; Czech Republic: Tardyferon; Denmark: Ferro Duretter; Finland: Duroferon, Retafer; France: Fer AP-HP, Tardyferon; Germany: Aktiferrin N, Ceferro, Dreisafer, Eisensulfat, Eryfer 100, Ferrogamma, Haemoprotect, Hämatopan 50, Loma Eisen, Plastufer, Plastulen Eisen, Tardyferon; Greece: Fer-In-Sol, Resoferon, Tardyferon; Hungary: Ferro-Gradumet, Tardyferon; Ireland: Fer-In-Sol, Feospan Spansule, Ferrograd; Italy: Ferro-Grad, Ferros-S; Luxembourg: Fero-Gradumet, Tardyferon; Malta: Ferrograd; Netherlands: Fero-Gradumet, Ferrograd, Protiferron; Poland: Ferro Duo, Ferro-Gradumet, Hemofer Prolongatum, Tardyferon; Portugal: Ferro-Gradumet, Tardyferon; Romania: Ferro-Gradumet, Tardyferon; Spain: Fero-Gradumet, Tardyferon; Sweden: Duroferon; UK: Ferrous Sulphate.

North America

Canada: Ferofate, Ferrous Sulfate, Ferrum Sulfuricum, Novo-Ferrosulfate, Sulfate Ferreux; USA: Feosol, Fer-Gen-Sol, Fer-In-Sol, Fer-iron, Feratab, MyKidz Iron 10, Slow FE.

Latin America

Argentina: Eurofer, Factofer Gotas, Feklon, Fer-In-Sol, Ferrocebrina, Ferromas, Medifer, Siderblut, Sulfato Ferroso, TGI; Brazil: Cimefer, Fer-In-Sol, Ferrosol, Ferrototal-Sulfato Ferroso, Sulfato Ferroso, Sulfer Plus, Sulfergan Composto, Sulferro, Sulferrol, Vitafer; Mexico: Biofenor, Ferifer, Ferinsol, Hemobion, Sulfato Ferroso, Valdefer.


Japan: Fero gradumet, Slow-Fe, Tetucur.

Drug combinations

Ferrous Sulfate: Arsenic Acid; Ascorbic Acid (Vitamin C); Calcium Carbonate; Calcium Phosphate; Calcium Propionate; Carum carvi; Cobalt Sulfate; Copper Sulfate; Cyanocobalamin (Vitamin B~12~); Ergocalciferol (Vitamin D~2~); Foeniculum vulgare; Folic Acid (Vitamin B~9~); Glycine; Magnesium Carbonate; Manganese; Manganese Sulfate; Mercurius solubilis hahnemanni; Niacinamide; Pyridoxine (Vitamin B~6~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Sodium Chloride; Sodium Nitrate; Sodium Propionate; Stibium sulfuratum aurantiacum; Thiamine (Vitamin B~1~); Tocopherol (Vitamin E); Zinc Oxide; Zinc Sulfate


Ferrous Sulfate: FeSO~4~ 7H~2~O Mw: 278.01. Sulfuric acid, iron (2+) salt (1:1), heptahydrate. CAS-7782-63-0; CAS-7720-78-7 (anhydrous).

Pharmacologic Category

Antianemia Drugs; Iron Preparations. Iron Salt. (ATC-Code: B03AA07; B03AD03).

Mechanism of action

Replaces iron, found in hemoglobin, myoglobin, and other enzymes. Allows transportation of oxygen via hemoglobin.

Therapeutic use

Prevention and treatment of iron-deficiency anemias.

Pregnancy and lactiation implications

Except in severe cases of maternal anemia, the fetus achieves normal iron stores regardless of maternal concentrations. Amount of iron in breast milk generally not influenced by maternal iron status.

Unlabeled use


Hypersensitivity to iron salts or any component of the formulation. Hemochromatosis, hemolytic anemia.

Warnings and precautions

Severe iron toxicity may occur in overdose, particularly when ingested by children. Avoid in peptic ulcer, enteritis, or ulcerative colitis, in patients receiving frequent blood transfusions, in premature infants until vitamin E stores are replenished.



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