Ferumoxytol
- Atc Codes:B03A
- CAS Codes:1309-38-2
- PHARMGKB ID:1309-38-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Feraheme.
Drug combinations
Chemistry
Ferumoxytol: Fe~5874~O~8752~C~11719~H~18682~O~9933~Na~414~ (overall colloidal particle). Mw: 750. Superparamagnetic iron oxide coated with polyglucose sorbitol carboxymethylether. CAS-1309-38-2.
Pharmacologic Category
Antianemia Drugs; Iron Preparations. Iron Salt. (ATC-Code: B03A).
Mechanism of action
Superparamagnetic iron oxide coated with a low molecular weight semisynthetic carbohydrate; iron-carbohydrate complex enters the reticuloendothelial system macrophages of the liver, spleen, and bone marrow where the iron is released from the complex. The released iron is either transported into storage pools or is transported via plasma transferrin for incorporation into hemoglobin.
Therapeutic use
Iron replacement product indicated for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD).
Pregnancy and lactiation implications
Use ferumoxytol during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to ferumoxytol or any component of the formulation; evidence of iron overload; anemia not caused by iron deficiency.
Warnings and precautions
Hypersensitivity reactions have been observed. May cause hypotension. Iron overload may occur. Can alter magnetic resonance imaging (MRI) studies.