Finasteride
- Atc Codes:D11AX10#G04CB01
- CAS Codes:98319-26-7
- PHARMGKB ID:98319-26-7
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Androfin, Crinormin, Finastad, Finasterid, Prezepa, Propecia, Proscar; Belgium: Finasteride, Proscar; Bulgaria: Finanorm, Hyplafin, Penester, Prezepa, Propecia, Proscar; Cyprus: Impruve, Propecia, Proscar; Czech Republic: Androfin, Apo-Finas, Duromeran, Edufil, Finajelf, Finanorm, Finard, Finasterid, Finasteride, Finex, Finpros, Gefin, Ibition, Lekoprost, Mostrafin, Penester, Propecia, Radicut; Denmark: Finasterid, Propecia, Proscar; Estonia: Androfin, Finasterid, Finasteride, Finpros, Penester, Propecia, Ulgafen; Finland: Finasterid, Gefina, Propecia, Proscar, Tifisterid; France: Chibro-Proscar, Finasteride, Propecia; Germany: Crinormin, Deltafin, Fina-TEVA, Finafrank, Finafried, FinaHAIR, Finamed, Finapart, Finapecia, Finascar, Finasterid, Finis, Finural, Propecia, Proscar, Prosmin; Greece: Alsteride, Finar, Finasteride, Finazil, Fisterid, Profin, Profinosa, Prohype, Propecia, Proplasia, Proscar, Prostafin; Hungary: Andofin, Finanorm, Finasted, Finasterid, Finasteride, Finpros, Hyplafin, Proscar, Prosterid; Ireland: Finasteride, Finocard, Fintex, Fintrid, Profal, Proscar; Italy: Asterid, Finasteride, Finastid, Finerid, Folians, Genaprost, Pilus, Propecia, Proscar, Prostide, Ridestin; Latvia: Androfin, Finasterid, Finasteride, Finster, Penester, Proscar, Prostarinol, Ulgafen; Lithuania: Androfin, Finasterid, Finasteride, Finster, Penester, Ulgafen; Luxembourg: Proscar; Malta: Finasteride, Propecia, Proscar; Netherlands: Finasteride, Propecia, Proscar; Poland: Ambulase, Androstatin, Antiprost, Apo-Fina, Aprost, FinaGen, Finamef, Finaran, Finaride, Finaster, Finasterid, Finasteride, Finasteridum, Finasteryd, Fincar, Finpros, Fintral, Finxta, Hyplafin, Lifin, Penester, Propecia, Proscar, Reduprost, Symasteride, Ulgafen, Zasterid; Portugal: Binprós, Finasterida, Finox, Growancer, Propecia, Proscar, Prostacide, Prostafin, Zidoril; Romania: Enyde, Finanorm, Finasterid, Finasterida, Finasteride, Mostrafin, Propecia, Proscar, Taredox; Slovakia: Finajelf, Finanorm, Finasterid, Finpros, Penester; Slovenia: Finpros, Hyplafyn, Mostrafin, Propecia, Prostide; Spain: Finasterida, Litace, Propecia, Proscar; Sweden: Capipro, Erastafin, Finasterid, Finasteride, Finementin, Finoplasa, Finpros, Profina, Propecia, Proscar, Prosmin, Ridafinatabs, Teridisol; UK: Propecia, Proscar.
North America
Canada: Propecia, Proscar; USA: Propecia, Proscar.
Latin America
Argentina: Andropel, Avertex, Daric, Finasteride, Finasterin, Finterac, Flutiamik, Folcres, HPB Panalab, IVIX Fin, Nasteril, Propecia, Proscar, Prosmin, Prostanil, Prostanovag, Prostene, Q-prost, Renacidin, Sutrico, Tealep, Tresaride, Tricofarma, Urofin, Urototal, Vetiprost; Brazil: Alfasyn, Capyla, Fendical, Finalop, Finastec, Finasterida, Finastil, Flaxin, Nasterid, Pracap, Pro Hair, Pronasteron-Finasteride, Propecia, Proscar, Prostide; Mexico: Fhilterin, Propeshia, Proscar, Riterid-Z, Vanorid.
Asia
Japan: Propecia.
Drug combinations
Finasteride and Tamsulosin
Chemistry
Finasteride: C~23~H~36~N~2~O~2~. Mw: 372.54. (1) 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5α,17β)-; (2) N-tert-butyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide. CAS-98319-26-7 (1989).
Pharmacologic Category
5-α-Reductase Inhibitors. (ATC-Code: D11AX10; G04CB01).
Mechanism of action
Finasteride is a competitive inhibitor of both tissue and hepatic 5-α-reductase. This results in inhibition of conversion of testosterone to dihydrotestosterone, and markedly suppresses serum dihydrotestosterone levels.
Therapeutic use
Finasteride is used to reduce prostatic size, urinary obstruction and associated manifestations (e.g. urinary hesitancy and/or urgency, nocturia), risk of acute urinary retention, and of need for surgery (including transurethral resection of prostate and prostatectomy) in symptomatic benign prostatic hyperplasia.
Pregnancy and lactiation implications
Abnormalities of external male genitalia reported in animal studies. Pregnant women should avoid contact with crushed or broken tablets. Not indicated for use in women.
Unlabeled use
Adjuvant monotherapy after radical prostatectomy in treatment of prostatic cancer. Female hirsutism.
Contraindications
Hypersensitivity to finasteride or any component of the formulation. Pregnancy. Not for use in children.
Warnings and precautions
Hazardous agent. Pregnant women or women trying to conceive should not handle the product. Use with caution in hepatic impairment. Other urological diseases including cancer should be ruled out before initiating. Duration of therapy minimum 6 months. Reduces prostate specific antigen (PSA) by 50%.