Flavocoxid
- Atc Codes:M01AH
- CAS Codes:21967-41-9#154-23-4
- PHARMGKB ID:21967-41-9#154-23-4
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Inhibits
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Limbrel.
Drug combinations
Chemistry
Flavocoxid: Consists of a proprietary blend of two types of flavonoids, Free-B-Ring flavonoids (baicalin) and flavans (catechin), from Scutellaria baicalensis and Acacia catechu, respectively. CAS-21967-41-9 (baicalin); CAS-154-23-4 (catechin).
Pharmacologic Category
Nonsteroidal Anti-inflammatory Agents; Cyclooxygenase-2 (COX-2) Inhibitors. (ATC-Code: M01AH).
Mechanism of action
Exerts anti-inflammatory properties through nonspecific inhibition of cyclooxygenase (COX/PTGS) and lipoxygenase (ALOX5) pathways. May also possess general analgesic and antioxidant/anticytokine properties.
Therapeutic use
Clinical dietary management of osteoarthritis, including associated inflammation.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to flavocoxid or any component of the formulation.
Warnings and precautions
May cause GI bleeding or ulceration (use with caution in history of GI disorders). Avoid concomitant use with NSAIDs.