Does not consistently reverse amnesia (patient may not recall verbal instructions after procedure). Resedation: Occurs more frequently where a large single dose or cumulative dose of a benzodiazepine has been administered along with a neuromuscular-blocking agent and multiple anesthetic agents. Benzodiazepine reversal may result in seizures in some patients (use with caution in patients relying on a benzodiazepine for seizure control). Use with caution in head injury, hepatic dysfunction, or panic disorder. Use caution in drug and ethanol-dependent patients. Not recommended for treatment of benzodiazepine dependence. Use with caution in mixed drug overdoses. Use not recommended in manifestations of serious cyclic antidepressant poisoning (e.g. twitching, rigidity, focal seizure, wide QRS, ventricular dysrhythmia, heart block, mydriasis, dry mucosa, hypoperistalsis, cardiovascular collapse). Possible local pain or inflammation at injection site following extravasation. Not recommended as primary treatment of patients with serious lung disease who experience serious respiratory depression secondary to benzodiazepines.