Flunarizine
- Atc Codes:N07CA03
- CAS Codes:30484-77-6#52468-60-7
- PHARMGKB ID:30484-77-6#52468-60-7
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Flunarium, Sibelium; Belgium: Flunarimed, Flunatod, Flunarizine, Sibelium; Bulgaria: Flunarizin, Sibelium; Czech Republic: Sibelium; Denmark: Sibelium; France: Sibelium; Germany: Dilavert, Flunarizin, Flunavert, Natil-N, Segus, Sibelium; Greece: Sibelium; Hungary: Sibelium; Ireland: Sibelium; Italy: Flugeral, Flunagen, Fluxarten, Gradient, Issium, Sibelium; Netherlands: Flunarizine, Sibelium; Poland: Flunarizinum; Portugal: Flunarizina; Spain: Flerudin, Flurpax, Sibelium.
North America
Canada: Flunarazine.
Latin America
Argentina: Bercetina, Coromert, Flufenal, Mondus, Niflucan, Sibelium; Brazil: Flunarin, Fluvert, Sibelium, Vertigium, Vertix; Mexico: Fasolan, Nafluryl Or, Sibelium.
Drug combinations
Flunarizine and Nicergoline
Chemistry
Flunarizine Hydrochoride: C~26~H~26~F~2~N~2~ 2HCl. Mw: 477.42. (1) Piperazine, 1-[bis(4-fluorophenylmethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-; (E)-1-[bis-(p-Fluorophenyl)methyl]-4-cinnamylpiperazine hydrochoride. CAS-30484-77-6; CAS-52468-60-7 (flunarazine)(1970).
Pharmacologic Category
Central Nervous System Agents, Miscellaneous; Calcium Channel Antagonist. (ATC-Code: N07CA03).
Mechanism of action
Flunarizine is a selective calcium channel antagonist which prevents cellular calcium overload by reducing transmembrane calcium influx. Also has antihistamine properties.
Therapeutic use
Prophylaxis of classic (with aura) or common (without aura) migraine. Symptomatic treatment of vestibular vertigo (due to diagnosed functional disorder of vestibular system).
Pregnancy and lactiation implications
No data to support use during pregnancy. Weigh benefits vs potential risks. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to flunarizine, any component of the formulation, or other calcium channel antagonists. Depression. Parkinson’s disease, or other extrapyramidal disorders.
Warnings and precautions
Flunarizine may cause CNS depression. May precipitate depression (greater risk in younger patients). May produce extrapyramidal symptoms in individuals with no prior history of neurological deficits (increased risk in elderly patients). Not indicated for treatment of acute migraine attacks. Caution warranted in severe hepatic impairment.