Fluoride
- Atc Codes:A12CD
Table of contents
- Brand Names
- Drug Combinations
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Duraphat, Fluodont, Zymafluor; Belgium: Zymafluor; Bulgaria: Zymafluor; Cyprus: Fluodontyl; Czech Republic: Natrium Fluoratum, Zymafluor; Denmark: Duraphat, Fluorolex; Finland: Duraphat, Fludent, Fluorilette; France: Duraphat, Fluodontyl, Fluor, Fluorex, Oligosol Fluor, Oligostim Fluor, Sanogyl Blanc, Zymafluor; Germany: Alpen-Sol-Bad, Controcar, Duraphat, Fluoretten, Fluoridin N5, Fluoros, Natrium Fluoratum D4, Natriumfluorid, Ossin, Septogel, Zymafluor; Greece: Apoflux, Dentaflux, Fluocaril, Flurexil; Hungary: Dentocar, Zymafluor; Ireland: Duraphat; Italy: Duraphat, Sod Fluo, Zymafluor; Luxembourg: Fluodontyl, Natriumfluorid, Procal, Zymafluor; Netherlands: Duraphat, Dentigel, Zymafluor; Poland: Duraphat, Floam, Fluormex, Natrium Fluoratum, Zymafluor; Romania: Duraphat, Zymafluor; Slovakia: Fluossen, Natrium Fluoratum; Spain: Fluodontyl; Sweden: Dentan, Duraphat, Fludent, Fluorette; UK: Luborant.
North America
Canada: Aquafresh Multi-Action Whitening, Denti-Care Prophylaxis Paste With Fluoride, Fluocal Solution, Nafrinse-Regular, Natrum Fluoratum, Neutral Sodium Fluoride Gel, Oligostim Fluor, Perfect Solutions Prophy Paste, Solu Flur Powder.
Asia
Japan: Butler Fluodent Foam N, Diadent, Fluoden A, Fluoll, Fluorident, F Varnish, Miranol, Ora-Bliss.
Drug combinations
Fluoride and Calcium Carbonate
Fluoride and Triclosan
Fluoride, Erythrosin, and Xylitol
Other Fluoride combinations: Ascorbic Acid (Vitamin C); Aspartame; Cholecalciferol (Vitamin D~3~); Chromium Chloride; Cobalt; Copper; Cyanocobalamin (Vitamin B~12~); Ergocalciferol (Vitamin D~2~); Ginseng; Iron; Magnesium; Manganese; Niacinamide; Phosphorus; Potassium; Povidone Iodide; Pyridoxine (Vitamin B~6~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Sodium; Sodium Chloride; Sodium Selenite; Syzygium aromaticum; Thiamine (Vitamin B~1~); Tocopherol (Vitamin E); Zinc Chloride
Chemistry
Pharmacologic Category
Cariostatic Agents. Nutritional Supplement. (ATC-Code: A12CD).
Mechanism of action
Promotes remineralization of decalcified enamel. Inhibits cariogenic microbial process in dental plaque. Increases tooth resistance to acid dissolution.
Therapeutic use
Prevention of dental caries.
Pregnancy and lactiation implications
Use with caution in pregnant and nursing women.
Unlabeled use
Contraindications
Hypersensitivity to fluoride, tartrazine, or any component of the formulation. When fluoride content of drinking water exceeds 0.7 ppm. Low sodium or sodium-free diets. Do not use 1 mg tablets in children <3 years of age or when drinking water fluoride content is ≥0.3 ppm. Do not use 1 mg/5 mL rinse (as supplement) in children <6 years of age.
Warnings and precautions
Prolonged ingestion with excessive doses may result in dental fluorosis and osseous changes. Some products contain tartrazine.