Flutamide
- Atc Codes:L02BB01
- CAS Codes:13311-84-7
- PHARMGKB ID:13311-84-7
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Flutabene, Flutastad, Fugerel; Belgium: Eulexin, Flutamide, Flutaplex; Bulgaria: Flucinom, Flutamide, Flutasin; Cyprus: Codalan, Elbat, Flutan, Prosneo; Czech Republic: Flucinom, Flumed, Flutamid, Flutamide, Flutaplex; Denmark: Eulexin, Fluprosin, Flutaplex, Profamid; Finland: Eulexin, Profamid; France: Eulexine, Flutamide, Prostadirex; Germany: Apimid, Flumid, Fluta-GRY, Flutamid, Fugerel, Prostica; Greece: Andraxan, Elbat, Flucinom, Flumidon, Flutamide, Flutaplex, Palistop, Palliaril, Prostamide, Rikital, Tremexal, Zeroprost; Hungary: Fluprost, Flutam, Flutasin, Fugerel, Prosztika; Ireland: Drogenil, Prostamide; Italy: Eulexin, Fluprost, Flutamide, Ricalide; Latvia: Flutan, Flutaplex, Profamid; Lithuania: Flutaplex; Luxembourg: Bedozane, Eulexin, Flutacan; Malta: Flutamide; Netherlands: Flutamide, Flutaplex; Poland: Apo-Flutam, Flutacan, Flutamid, Flutamide, Fugerel; Portugal: Drogenil, Eulexin, Flutamida, Prosneo; Romania: Flutamide, Flutan, Flutasin; Slovakia: Androhexal, Flucinom, Flutasin; Slovenia: Flucinom; Spain: Eulexin, Flutamida, Grisetin, Oncosal, Prostacur; Sweden: Eulexin, Flutamid.
North America
Canada: Euflex, Flutamide; USA: Flutamide.
Latin America
Argentina: Asoflut, Dedile, Flutamida, Flutepan, Flutrax; Brazil: Eulexin, Flutamida, Tecnoflut, Teflut; Mexico: Flimutal, Flulem, Tafenil.
Asia
Japan: Flutamerck, Odyne.
Drug combinations
Flutamide and Leuprolide
Chemistry
Flutamide: C~11~H~11~F~3~N~2~O~3~. Mw: 276.21. (1) Propanamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-; (2) α,α,α-Trifluoro-2-methyl-4′-nitro-m-propionotoluidide. CAS-13311-84-7 (1975).
Pharmacologic Category
Antineoplastic Agents; Endocrine Therapy; Antiandrogen. (ATC-Code: L02BB01).
Mechanism of action
Nonsteroidal antiandrogen which inhibits androgen uptake or binding of androgen in target tissues.
Therapeutic use
Used in combination with a gonadotropin-releasing hormone (GnRH) analog (e.g. goserelin, leuprolide acetate) in treatment of prostate cancer.
Pregnancy and lactiation implications
May cause fetal harm if used in pregnant women.
Unlabeled use
Female hirsutism.
Contraindications
Hypersensitivity to flutamide or any component of the formulation. Severe hepatic impairment. Pregnancy.
Warnings and precautions
Hazardous agent. Patients with hemoglobin M disease, G6PD deficiency, or patients who smoke, are at risk of toxicities associated with aniline exposure (i.e. methemoglobinemia, hemolytic anemia, cholestatic jaundice). Photosensitivity reactions (e.g. erythema, ulceration, bullous eruptions, epidermal necrolysis) reported. Contraindicated in severe hepatic impairment. Liver failure reported (avoid use in patients whose ALT values are greater than twice the upper limit of normal).