Folic Acid (Vitamin B9)
- Atc Codes:B03BB01
- CAS Codes:59-30-3
- PHARMGKB ID:59-30-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Folsan; Belgium: Folavit; Bulgaria: Folic Acid; Cyprus: Folicil, Lexpec; Czech Republic: Acidum Folicum; Denmark: Folimet; Finland: Foliver, Folvite; France: Acide Folique, Speciafoldine; Germany: Bio-Fol, DreisaFol, Fol Lichtenstein, Fol-5 Biomo, Fol-Asmedic, Folarell, Folcur, Folgamma Mono, Folic Denk 5, Folicum, FolisYX Folsäure, Folsan, Folsäure, Folverlan, Gravi-Fol, Innovafolat, Lafol, Ren-o-fol, RubieFol; Greece: Filicine, Folidex; Hungary: Atherovit, Eurovit, Folsav, Huma-Folacid; Ireland: Clonfolic, Folic Acid, Preconceive; Italy: Fertifol, Folidex, Folina; Malta: Filicine, Folic Acid, Folicil, Preconceive; Netherlands: Foliumzuur; Poland: Acidum Folicum, Acifolik, Folacid, Folidex, Folifem, Folifort, Folik, Folimin, Folovit, Kwas Foliowy; Portugal: Acfol, Folicil, Folidex, Fovital; Romania: Acifol; Slovakia: Acidum Folicum; Slovenia: Folacin, Tifol; Spain: Acfol, Ácido Fólico, Bialfoli, Zolico; Sweden: Folacin; UK: Folic Acid, Folicare, Lexpec Folic Acid.
North America
Canada: Apo-Folic, Acide Folique, Euro Folic, Folic Acid, Novo-Folacid.
Latin America
Argentina: Ácido Fólico, Acifol, Anemidox Fólico, Anfolic, Arisfolic, Azolac Fólico, Biolfolic, Coflic, Conacid, Egestan Fólico, Folacina, Folaport, Folimax, Folinemic, Galfol, Gynofol, Livifol, Medifol, Ronfolic, Suprafol, Tanvimil Fólico; Brazil: Afopic, Endofolin, Enfol, Folacin, Folital, Materfolic, Neo Fólico; Mexico: Ácido Fólico, Folivital, Materfol, Precileucin, Prinac AC.
Asia
Japan: Foliamin.
Drug combinations
Folic Acid: Acidum lacticum; Ascorbic Acid (Vitamin C); Aspartic Acid; Beta-Alanine; Beta-Carotene; Biotin (Vitamin B~7~); Calcium Carbonate; Calcium Phosphate, Tribasic; Centella asiatica; Cholecalciferol (Vitamin D~3~); Cholesterolum; Coenzyme Q~10~; Conium maculatum; Copper; Copper Sulfate; Cyanocobalamin (Vitamin B~12~); Ergocalciferol (Vitamin D~2~); Ferrous Fumarate; Ferrous Sulfate; Ginkgo biloba; Ginseng; Glycine; Glycocholic Acid; Hawthorn; Histidine; Hydroxocobalamin (Vitamin B~12a~); Inositol; Iodine; Ipriflavone; Iris versicolor; Iron; Iron Dextran; Isoleucine; L-Arginine; L-Carnitine; L-Cysteine; L-Glutamic; L-Glutamine; L-Histidine; Linoleic Acid; Linolenic Acid; L-Isoleucine; L-Leucine; L-Lysine; L-Proline; L-Valine; Manganese; Magnesium; Magnesium Oxide; Methionine; Niacin (Vitamin B~3~); Niacinamide; Pantothenic Acid (Vitamin B~5~); Paullinia cupana; Phenylalanine; Phosphorus; Phytomenadione (Vitamin K~1~); Pollen; Potassium Chloride; Pyridoxine (Vitamin B~6~); Riboflavin (Vitamin B~2~); Saccharomyces cerevisiae; Selenium; Sodium; Strychnos nux-vomica; Syzygium cumini; Thiamine (Vitamin B~1~); Threonine; Tocopherol (Vitamin E); Zinc; Zinc Gluconate.
Chemistry
Folic Acid: C~19~H~19~N~7~O~6~. Mw: 441.40. (1) L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; (2) N-[p-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. CAS-59-30-3.
Pharmacologic Category
Vitamins; Vitamin B Complex. (ATC-Code: B03BB01).
Mechanism of action
Folic acid is a water-soluble, B complex vitamin. Required for nucleoprotein synthesis and maintenance in erythropoiesis. Stimulates white blood cell and platelet production in folate deficiency anemia. Enhances elimination of formic acid, the toxic metabolite of methanol (unlabeled use).
Therapeutic use
Treatment of megaloblastic and macrocytic anemias due to folate deficiency. Dietary supplement to prevent neural tube defects.
Pregnancy and lactiation implications
Deficiency of folic acid during pregnancy may result in fetal harm.
Unlabeled use
Adjunctive cofactor therapy in methanol toxicity (alternative to leucovorin).
Contraindications
Hypersensitivity to folic acid or any component of the formulation.
Warnings and precautions
Not appropriate for monotherapy with pernicious, aplastic, or normocytic anemias when anemia is present with vitamin B~12~ deficiency. Injection contains benzyl alcohol as preservative, associated with «gasping syndrome» in neonates. Resistance to treatment may occur with depressed hematopoiesis, alcoholism, and deficiencies of other vitamins.