Fomepizole
- Atc Codes:V03AB34
- CAS Codes:7554-65-6
- PHARMGKB ID:7554-65-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Fomepizole; Czech Republic: Fomepizole; Finland: Fomepizole; France: Fomepizole; Germany: Fomepizole; Greece: Fomepizole; Ireland: Fomepizole; Netherlands: Fomepizole; Sweden: Fomepizole; UK: Antizol.
North America
Canada: Antizol; USA: Antizol, Fomepizole.
Drug combinations
Chemistry
Fomepizole: C~4~H~6~N~2~. Mw: 82.10. 1H-Pyrazole, 4-methyl-. CAS-7554-65-6 (1990).
Pharmacologic Category
Antidotes. (ATC-Code: V03AB34).
Mechanism of action
Fomepizole competitively inhibits alcohol dehydrogenase, an enzyme which catalyzes metabolism of ethanol, ethylene glycol, and methanol to their toxic metabolites.
Therapeutic use
Treatment of methanol or ethylene glycol poisoning alone or in combination with hemodialysis.
Pregnancy and lactiation implications
Caution if used during pregnancy or lactation.
Unlabeled use
Treatment of propylene glycol toxicity.
Contraindications
Hypersensitivity to fomepizole, other pyrazoles, or any component of the formulation.
Warnings and precautions
Mild rash and eosinophilia reported. Transient increases in serum transaminase concentrations and eosinophilia reported following repeated dosing. Vein irritation and phlebosclerosis reported following rapid I.V. infusion or I.V. injection. Acidosis and electrolyte imbalances can affect cardiovascular system. Consider potential interaction with alcohol. Use with caution in hepatic impairment (drug metabolized in liver), or renal impairment (drug excreted in urine).