Gatifloxacin
- Atc Codes:J01MA16#S01AX21
- CAS Codes:180200-66-2
- PHARMGKB ID:180200-66-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
Canada: Zymar; USA: Zymar, Zymaxid.
Latin America
Argentina: Gatif, Zymaran; Brazil: Zymar; Mexico: Zymar.
Asia
Japan: Gatiflo.
Drug combinations
Chemistry
Gatifloxacin: C~19~H~22~FN~3~O~4~ 1½H~2~O. Mw: 402.42. (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, sesquihydrate. CAS-180200-66-2 (1997).
Pharmacologic Category
EENT Preparations; Antibacterials; Quinolone. Ophthalmic Antibiotic. (ATC-Code: J01MA16; S01AX21).
Mechanism of action
Gatifloxacin is a DNA gyrase inhibitor. Like other fluoroquinolones, gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV. Usually bactericidal.
Therapeutic use
Treatment of conjunctivitis caused by susceptible Corynebacterium propinquum, Staphylococcus aureus, S. epidermidis, Streptococcus mitis, S. pneumoniae, or Haemophilus influenzae.
Pregnancy and lactiation implications
Gatifloxacin shown to be fetotoxic in animal studies. There are no adequate, well-controlled studies in pregnant women. Caution if administered while nursing.
Unlabeled use
Contraindications
Hypersensitivity to gatifloxacin, other quinolone antibiotics, or any component of formulation.
Warnings and precautions
Hypersensitivity reactions (i.e. dermatologic, vascular, pulmonary, renal, hepatic, and/or hematologic events). Fungal or bacterial superinfection may result (with prolonged use). Contact lenses should not be worn during treatment. May have potential to prolong QT interval (should be avoided in uncorrected hypokalemia, or concurrent administration of other medications known to prolong the QT interval (antipsychotics, tricyclic antidepressants, ziprasidone)).