Hepatitis B Immune Globulin
- Atc Codes:J06BB04
Table of contents
- Brand Names
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Hepatect; Belgium: Hepacaf; Bulgaria: Hepatect; France: IVheBex; Germany: Hepatect; Greece: Igantibe, ImmunoHBS; Ireland: Hepatect; Malta: Human Hepatitis B Immunoglobulin; Netherlands: HepBQuin, Hepatitis B Immunoglobuline, Hepatect, IVheBex; Poland: Hepatect; Portugal: Gammaglobulina Antihepatitis B P, Hepatect, IvheBex, Uman Big, Venbig; Romania: Hepatect, IvheBex; Slovakia: Hepatect, Pasteurised Human Antihepatitis B Immunoglobulin; Spain: Gamma Antihepatitis B, Niuliva; Sweden: Omrihepb, Umanbig, Venbig; UK: Human Hepatitis B Immunoglobulin.
North America
Canada: HepaGam B, HyperHEP B; USA: HepaGam B, HyperHEP B, Nabi-HB.
Latin America
Argentina: Antib CP, Igantibe, Inmunoglobulina Antihepatitis-B P; Mexico: Gammaglobulina Antihepatitis-B P.
Drug combinations
Chemistry
Pharmacologic Category
Serums, Toxoids, and Vaccines; Serums. Immune Globulin. (ATC-Code: J06BB04).
Mechanism of action
Hepatitis B immune globulin (HBIG) is nonpyrogenic sterile solution containing immunoglobulin G (IgG) specific to hepatitis B surface antigen (HB~s~Ag).
Therapeutic use
Passive prophylactic immunity to hepatitis B following acute exposure to blood containing HB~s~Ag, perinatal exposure of infants born to HB~s~Ag-positive mothers, sexual exposure to HB~s~Ag-positive persons, household exposure to acute HBV infection. Prevention of hepatitis B virus recurrence after liver transplantation in HB~s~Ag-positive transplant patients.
Pregnancy and lactiation implications
Caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to HBIG or any component of the formulation. Severe allergy to γ-globulin or anti-immunoglobulin therapies.
Warnings and precautions
Use caution in history of systemic allergic reactions to immune globulins. Hypersensitivity and anaphylactic reactions can occur. Use with caution in thrombocytopenia or coagulation disorders. Product of human plasma. Some products may contain maltose.