Homatropine
- Atc Codes:S01FA05
- CAS Codes:51-56-9#87-00-3
- PHARMGKB ID:51-56-9#87-00-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Isopto Homatropine; Greece: Nopar Uni-Pharma; Hungary: Troparin; Ireland: Minims Homatropine; Italy: Omatr BR FN, Omatropina; Luxembourg: Bromhydrate d’homatropine; Netherlands: Homatropinehydrobromide; Spain: Homatropina.
North America
Canada: Isopto Homatropine.
Latin America
Argentina: Dallapasmo, Homatropina, Paratropina; Brazil: Novatropina; Mexico: Homogrin, Infafren Simple.
Drug combinations
Homatropine and Dimethicone
Homatropine and Dipyrone
Homatropine and Hydrocodone
Homatropine and Ibuprofen
Homatropine and Methscopolamine
Homatropine and Scopolamine
Homatropine and Simethicone
Homatropine, Activated Carbon, and Phthalylsulfathiazole
Homatropine, Benactyzine, and Pentobarbital
Homatropine, Bendroflumethiazide, and Dipyrone
Homatropine, Dipyrone, and Papaverine
Homatropine, Aluminum Hydroxide, Magnesium Trisilicate, and Phenylbutazone
Homatropine, Dehydrocholic Acid, Magnesium Bile Salts, Pancreatin, and Silymarin
Chemistry
Homatropine Hydrobromide: C~16~H~21~NO~3~ HBr. Mw: 356.25. (1) Benzeneacetic acid, α-hydroxy-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, hydrobromide, endo-(±)-; (2) 1αH,5αH-Tropan-3α-ol mandelate (ester) hydrobromide. CAS-51-56-9; CAS-87-00-3 (homatropine).
Pharmacologic Category
EENT Preparations; Mydriatics; Ophthalmic Cholinergic Antagonist. (ATC-Code: S01FA05).
Mechanism of action
Blocks response of iris sphincter muscle and accommodative muscle of ciliary body to cholinergic stimulation resulting in dilation and loss of accommodation.
Therapeutic use
Used to produce cycloplegia and mydriasis for refraction. Treatment of acute inflammatory conditions of uveal tract. Used for pre- and postoperative states when mydriasis is required. Optical aid in axial lens opacities.
Pregnancy and lactiation implications
Caution when used during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to homatropine or any component of the formulation. Primary glaucoma or predisposition to glaucoma (e.g. narrow-angle glaucoma).
Warnings and precautions
Caution in keratoconus (homatropine may produce fixed dilated pupil), Down’s syndrome (predisposed to angle-closure glaucoma), and children with brain damage. Excessive use, especially in children, geriatric patients, or other susceptible individuals, may produce adverse systemic antimuscarinic effects, including delirium, agitation, and coma. May cause increased intraocular pressure. May cause sensitivity to light. May result in fixed pupil dilation in keratoconus. Use with caution in pediatric and elderly patients due to susceptibility to systemic effects. May contain benzalkonium chloride which may be adsorbed by contact lenses.