Huperzine A (Huperzia serrata Thunb.)

Table of contents

  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Genes that may be involved
  • Drug Interactions

Brand Names

Drug combinations

Chemistry

Pharmacologic Category

Natural Products; Herbs.

Mechanism of action

In the 1980s, scientists showed that purified huperzine A prevented breakdown of acetylcholine.

Therapeutic use

Myasthenia gravis. Senile dementia and Alzheimer’s disease.

Pregnancy and lactiation implications

Unlabeled use

Contraindications

Based on pharmacologic activity, use with caution in individuals taking other acetylcholinesterase inhibitors.

Warnings and precautions

Use with extreme caution in children <2 years of age and in pregnancy or lactation. Use with caution in individuals on medication and with pre-existing medical conditions. Herbs may cause transient adverse effects such as nausea, vomiting, and GI distress due to a variety of chemical constituents. Use caution in known allergies to plants.

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