Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: HCT; Bulgaria: Dehydratin, Disalunil, Hypothiazid, HypoDehydra; Cyprus: Didralin; Finland: Hydrex; France: Esidrix; Germany: Disalunil, Esidrix, HCT, Hydrochlorothiazide EZ; Greece: Diuren; Hungary: Hypothiazid; Italy: Esidrex, Idroclor; Latvia: Hypothiazid; Luxembourg: Dichlotride, Esidrex; Poland: Disalunil, Hydrochlorothiazidum; Romania: Nefrix; Slovakia: Hydrochlorothiazid; Spain: Esidrex, Hidrosaluretil; Sweden: Esidrex.

North America

Canada: Apo-Hydro, Hydrochlorothiazide, Novo-Hydrazide, Nu-Hydro, Urozide; USA: Hydrochlorothiazide, Microzide.

Latin America

Argentina: Diural, Diurex, Tandiur; Brazil: Clorana, Clorizin, Diurepina, Diuretil, Diurix, Drenol, Hidroclorotiazida, Hidroclorozil, Hidrolan, Hidromed, Hidroclor; Mexico: Rofucal.


Japan: Dichlotride, Newtolide, Pantemon.

Drug combinations

Hydrochlorothiazide and Acebutolol

Hydrochlorothiazide and Aliskiren

Hydrochlorothiazide and Amiloride

Hydrochlorothiazide and Atenolol

Hydrochlorothiazide and Benazepril

Hydrochlorothiazide and Bisoprolol

Hydrochlorothiazide and Candesartan

Hydrochlorothiazide and Captopril

Hydrochlorothiazide and Carvedilol

Hydrochlorothiazide and Cilazapril

Hydrochlorothiazide and Enalapril

Hydrochlorothiazide and Eprosartan

Hydrochlorothiazide and Fosinopril

Hydrochlorothiazide and Hydralazine

Hydrochlorothiazide and Irbesartan

Hydrochlorothiazide and Lisinopril

Hydrochlorothiazide and Losartan

Hydrochlorothiazide and Metoprolol

Hydrochlorothiazide and Methyldopa

Hydrochlorothiazide and Moexipril

Hydrochlorothiazide and Nerbivolol

Hydrochlorothiazide and Olmesartan

Hydrochlorothiazide and Propanolol

Hydrochlorothiazide and Quinapril

Hydrochlorothiazide and Ramipril

Hydrochlorothiazide and Reserpine

Hydrochlorothiazide and Spironolactone

Hydrochlorothiazide and Telmisartan

Hydrochlorothiazide and Triamterene

Hydrochlorothiazide and Valsartan

Hydrochlorothiazide and Zofenopril

Hydrochlorothiazide, Aliskiren, and Amlodipine

Hydrochlorothiazide, Amiloride, and Atenolol

Hydrochlorothiazide, Amiloride, and Timolol

Hydrochlorothiazide, Amlodipine, and Olmesartan

Hydrochlorothiazide, Amlodipine, and Valsartan

Hydrochlorothiazide, Bendroflumethiazide, and Propranolol

Hydrochlorothiazide, Hydralazine and Metoprolol

Hydrochlorothiazide, Propranolol, and Triamterene

Hydrochlorothiazide, Triamterene, and Verapamil


Hydrochlorothiazide: C~7~H~8~ClN~3~O~4~S~2~. Mw: 297.74. (1) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide; (2) 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. CAS-58-93-5.

Pharmacologic Category

Thiazide Diuretics. (ATC-Code: C03AA03).

Mechanism of action

Inhibits sodium reabsorption in distal tubules causing increased excretion of sodium and water as well as potassium and hydrogen ions.

Therapeutic use

Management of mild-to-moderate hypertension. Treatment of edema in congestive heart failure and nephrotic syndrome.

Pregnancy and lactiation implications

Thiazide diuretics may cause increased risk of congenital defects, as well as other complications to fetus or newborn, such as hypoglycemia, hypokalemia, hyponatremia, jaundice, and thrombocytopenia.

Unlabeled use

Treatment of lithium-induced diabetes insipidus.


Hypersensitivity to hydrochlorothiazide or any component of the formulation, thiazides, or sulfonamide-derived drugs. Anuria. Renal decompensation. Pregnancy.

Warnings and precautions

Electrolyte disturbances, such as hypokalemia, hypochloremic alkalosis, and hyponatremia can occur. Photosensitization might occur. Use in sulfonamide allergy is specifically contraindicated. Use with caution in prediabetes or diabetes mellitus (change in glucose control possible). Gout can be precipitated in certain patients. Use with caution in severe hepatic dysfunction, in moderate or high cholesterol concentrations, or in hypokalemia. Avoid in severe renal disease (ineffective). Can cause systemic lupus erythematosus exacerbation or activation.



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