Hydroxyzine
- Atc Codes:N05BB01
- CAS Codes:2192-20-3#68-88-2#10246-75-0
- PHARMGKB ID:2192-20-3#68-88-2#10246-75-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Atarax; Belgium: Atarax; Bulgaria: Atarax, Neurolax; Cyprus: Atarax; Czech Republic: Atarax; Denmark: Atarax; Finland: Atarax; France: Atarax, Hydroxyzine; Germany: AH3 N, Atarax, Elroquil N; Greece: Atarax, Efidac, Iremofar; Hungary: Atarax; Ireland: Ucerax; Italy: Atarax; Luxembourg: Atarax; Malta: Atarax; Netherlands: Atarax, Hydroxyzine; Poland: Atarax, Hydroxyzinum; Portugal: Atarax, Coraphene; Slovakia: Atarax; Spain: Atarax; Sweden: Atarax; UK: Atarax, Ucerax.
North America
Canada: Hydroxyzin, Hydroxyzine; USA: Hydroxyzine, Vistaril.
Latin America
Argentina: Ataraxone, Hyderax; Brazil: Hixizine, Prurizin; Mexico: Atarax.
Asia
Japan: Atarax, Disron, Hatanazin.
Drug combinations
Chemistry
Hydroxyzine Hydrochloride: C~21~H~27~ClN~2~O~2~ 2HCl. Mw: 447.83. (1) Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride, (±)-; (2)(±)-2-[2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol dihydrochloride. CAS-2192-20-3; CAS-68-88-2 (hydroxyzine).
Hydroxyzine Pamoate: C~21~H~27~ClN~2~O~2~ C~23~H~16~O~6~. Mw: 763.27. (±)-2-[2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol 4,4′-methylenebis[3-hydroxy-2-naphthoate] (1:1). CAS-10246-75-0.
Pharmacologic Category
Other Antihistamines; Histamine H~1~ Antagonist. Anxiolytics, Sedatives, and Hypnotics; Miscellaneous. Antiemetic. (ATC-Code: N05BB01).
Mechanism of action
Competes with histamine for H~1~-receptor sites on effector cells in GI tract, blood vessels, and respiratory tract. Possesses skeletal muscle-relaxing, bronchodilator, antihistamine, antiemetic, and analgesic properties.
Therapeutic use
Treatment of anxiety, as a preoperative sedative, antipruritic. Pruritus.
Pregnancy and lactiation implications
Use in early pregnancy contraindicated. Use not recommended during lactation.
Unlabeled use
Antiemetic. Ethanol withdrawal symptoms.
Contraindications
Hypersensitivity to hydroxyzine or any component of the formulation. Early pregnancy. SubQ, intra-arterial, or I.V. administration of injection.
Warnings and precautions
May cause CNS depression. Use with caution in narrow-angle glaucoma, prostatic hyperplasia and/or urinary stricture, asthma or COPD. Effects may be potentiated when used with other sedative drugs or ethanol. Anticholinergic effects not well tolerated in the elderly. Do not administer intravenously, subcutaneously or intra-arterially.