Iloprost
- Atc Codes:B01AC11
- CAS Codes:78919-13-8
- PHARMGKB ID:78919-13-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Ilomedin, Ventavis; Bulgaria: Ilomedin, Ventavis; Cyprus: Ilomedin, Ventavis; Czech Republic: Ilomedin, Ventavis; Denmark: Ilomedin, Ventavis; Estonia: Ventavis; Finland: Ilomedin, Ventavis; France: Ilomedine, Ventavis; Germany: Ilomedin, Ventavis; Greece: Ilomedin, Ventavis; Hungary: Ilomedin, Ventavis; Ireland: Ventavis; Italy: Endoprost, Ventavis; Latvia: Ventavis; Lithuania: Ventabis; Malta: Ventavis; Netherlands: Ilomedine, Ventavis; Poland: Ilomedin, Ventavis; Portugal: Ilomedin, Ventavis; Romania: Ilomedin, Ventavis; Slovakia: Ilomedin, Ventavis; Slovenia: Ilomedin, Ventabis; Spain: Ilomedin, Ventavis; Sweden: Ilomedin, Ventavis; UK: Ventavis.
North America
USA: Ventavis.
Latin America
Mexico: Ventavis.
Drug combinations
Chemistry
Iloprost: C~22~H~32~O~4~. Mw: 360.49. (1) Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)-; (2)(5E)-[3aS,4R,5R,6aS)-5-Hydroxy-4-[(1E)-(3S,4RS)-3-hydroxy-4-methyloct-1-en-6-ynyl]-hexahydropentalen-2(1H)-ylidene]pentanoic acid. CAS-78919-13-8 (2004).
Pharmacologic Category
Vasodilating Agents, Miscellaneous. Prostacyclin; Prostaglandin. Vasodilator. (ATC-Code: B01AC11).
Mechanism of action
Acutely, iloprost dilates systemic and pulmonary arterial vascular beds. With longer-term use, alters pulmonary vascular resistance and suppresses vascular smooth muscle proliferation.
Therapeutic use
Treatment of idiopathic pulmonary arterial hypertension in NYHA Class III or IV symptoms (designated orphan drug by FDA for this use).
Pregnancy and lactiation implications
Unlabeled use
Contraindications
None known to date.
Warnings and precautions
Risk of pulmonary edema. Syncope might occur (use caution with concurrent conditions or medications which may increase risk of syncope). Use with caution in active bleeding or at increased risk of bleeding (e.g. concomitant anticoagulation). Use with caution in hepatic impairment. Avoid use in hypotension (systolic BP <85 mm Hg). Use with caution in patients on dialysis; inhaled iloprost has not been evaluated in this population. Might induce bronchospasm in hyper-reactive airways. Not FDA labeled for use in children.