Indapamide
- Atc Codes:C03BA11
- CAS Codes:26807-65-8
- PHARMGKB ID:26807-65-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Fludex, Indapamid; Belgium: Docindapa, Fludex, Indapamide; Bulgaria: Impamid, Indipam, Mivara SR, Neopamid, Pisizif SR, Rawel SR, Sophtensif, Tertensif; Cyprus: Fludex, Frumeron; Czech Republic: Indap, Indapamid, Izepox, Rawel SR, Tertensif; Denmark: Indacar, Indapamid, Natrilix, Tertensif; Estonia: Indapamide, Proindap, Rawel SR, Tertensif; Finland: Indapamide, Natrilix, Tertensif; France: Indapamide; Germany: Indapamid, Natrilix; Greece: Fludex, Indapamide, Rawel SR; Hungary: Apadex, Indapamide, Fludex, Pretanix; Ireland: Agelan, Indapamide, Napamide PR, Natrilix; Italy: Damide, Indaflex, Indamol, Indapamide, Ipamix, Millibar, Natrilix, Pressural, Verolix; Latvia: Indapamide, Indatens, Proindap, Rawel SR, Tertensif; Lithuania: Indapamide, Indatens, Proindap; Luxembourg: Fludex, Indapamide; Malta: Indapamide, Natrilix, Nepamide PR; Netherlands: Fludex, Indapamide, Natrilix; Poland: Arifon, Diuresin SR, Fodrin, Indap, Indapamid, Indapamide, Indapamidum, Indapen, Indapres, Indapsan, Indastad, Indipam SR, Indix SR, Ipres Long, Previlex, Rawel SR, Terpamid SR, Tertensif; Portugal: Fludex, Fluidema, Indapamida, Norpress, Rawel LP, Vasodipin; Romania: Diuremid SR, Iduren Impamid, Indapamid, Indapamida, Indapamide, Indater, Izepox, Rawel SR, Tertensif, Valutens; Slovakia: Actapam, Apadex, Indap, Indapamid, Indapamide, Izepox, Rawel SR, Tertensif; Slovenia: Indapamid, Rawel SR; Spain: Extur, Indapamida, Tertensif; Sweden: Natrilix; UK: Indapamide, Indipan, Natrilix.
North America
Canada: Indapamide, Lozide; USA: Indapamide.
Latin America
Argentina: Bajaten, Indapamida, Natrilix, Noranat; Brazil: Indapen, Natrilix; Mexico: Natrilix.
Asia
Japan: Nashindolen, Natrix, Tenaxil.
Drug combinations
Indapamide and Perindopril Erbumine
Chemistry
Indapamide: C~16~H~16~ClN~3~O~3~S. Mw: 365.83. (1) Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-; (2) 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide. CAS-26807-65-8 (1979).
Pharmacologic Category
Thiazide-like Diuretics. (ATC-Code: C03BA11).
Mechanism of action
Diuretic effect localized at proximal segment of distal tubule of nephron. Enhances sodium, chloride, and water excretion by interfering with transport of sodium ions across renal tubular epithelium.
Therapeutic use
Management of hypertension, or of edema associated with CHF and nephrotic syndrome.
Pregnancy and lactiation implications
Diuretics cross placental barrier. Possibility of fetal or neonatal jaundice, thrombocytopenia, and other adverse effects reported in adults. Diuretics should not be used for routine therapy in healthy pregnant women with mild edema.
Unlabeled use
Contraindications
Hypersensitivity to indapamide or any component of the formulation, thiazides, or sulfonamide-derived drugs. Anuria. Renal decompensation. Pregnancy.
Warnings and precautions
Hyponatremia, hypokalemia, hypochloremic alkalosis, hypomagnesemia can occur. Photosensitization might occur. Use in thiazide or sulfonamide allergy contraindicated. Use with caution in prediabetes or diabetes mellitus (possible change in glucose control). Gout can be precipitated in certain risk patients. Use with caution in severe hepatic or renal dysfunction. Use with caution in moderate or high cholesterol concentrations. Can cause systemic lupus erythematosus exacerbation or activation. Rash (e.g. erythematous, maculopapular, morbilliform), urticaria, pruritus, and vasculitis reported. Erythema multiforme and epidermal necrolysis rarely reported. May decrease calcium urinary excretion. Use with caution in hyperparathyroidism or thyroid disorders. Antihypertensive effect may be enhanced after sympathectomy. Use with caution in geriatric patients (increased risk of dilutional hyponatremia or of hypokalemia).