Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Genes that may be involved
  • Substrate of
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Fludex, Indapamid; Belgium: Docindapa, Fludex, Indapamide; Bulgaria: Impamid, Indipam, Mivara SR, Neopamid, Pisizif SR, Rawel SR, Sophtensif, Tertensif; Cyprus: Fludex, Frumeron; Czech Republic: Indap, Indapamid, Izepox, Rawel SR, Tertensif; Denmark: Indacar, Indapamid, Natrilix, Tertensif; Estonia: Indapamide, Proindap, Rawel SR, Tertensif; Finland: Indapamide, Natrilix, Tertensif; France: Indapamide; Germany: Indapamid, Natrilix; Greece: Fludex, Indapamide, Rawel SR; Hungary: Apadex, Indapamide, Fludex, Pretanix; Ireland: Agelan, Indapamide, Napamide PR, Natrilix; Italy: Damide, Indaflex, Indamol, Indapamide, Ipamix, Millibar, Natrilix, Pressural, Verolix; Latvia: Indapamide, Indatens, Proindap, Rawel SR, Tertensif; Lithuania: Indapamide, Indatens, Proindap; Luxembourg: Fludex, Indapamide; Malta: Indapamide, Natrilix, Nepamide PR; Netherlands: Fludex, Indapamide, Natrilix; Poland: Arifon, Diuresin SR, Fodrin, Indap, Indapamid, Indapamide, Indapamidum, Indapen, Indapres, Indapsan, Indastad, Indipam SR, Indix SR, Ipres Long, Previlex, Rawel SR, Terpamid SR, Tertensif; Portugal: Fludex, Fluidema, Indapamida, Norpress, Rawel LP, Vasodipin; Romania: Diuremid SR, Iduren Impamid, Indapamid, Indapamida, Indapamide, Indater, Izepox, Rawel SR, Tertensif, Valutens; Slovakia: Actapam, Apadex, Indap, Indapamid, Indapamide, Izepox, Rawel SR, Tertensif; Slovenia: Indapamid, Rawel SR; Spain: Extur, Indapamida, Tertensif; Sweden: Natrilix; UK: Indapamide, Indipan, Natrilix.

North America

Canada: Indapamide, Lozide; USA: Indapamide.

Latin America

Argentina: Bajaten, Indapamida, Natrilix, Noranat; Brazil: Indapen, Natrilix; Mexico: Natrilix.


Japan: Nashindolen, Natrix, Tenaxil.

Drug combinations

Indapamide and Perindopril Erbumine


Indapamide: C~16~H~16~ClN~3~O~3~S. Mw: 365.83. (1) Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-; (2) 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide. CAS-26807-65-8 (1979).

Pharmacologic Category

Thiazide-like Diuretics. (ATC-Code: C03BA11).

Mechanism of action

Diuretic effect localized at proximal segment of distal tubule of nephron. Enhances sodium, chloride, and water excretion by interfering with transport of sodium ions across renal tubular epithelium.

Therapeutic use

Management of hypertension, or of edema associated with CHF and nephrotic syndrome.

Pregnancy and lactiation implications

Diuretics cross placental barrier. Possibility of fetal or neonatal jaundice, thrombocytopenia, and other adverse effects reported in adults. Diuretics should not be used for routine therapy in healthy pregnant women with mild edema.

Unlabeled use


Hypersensitivity to indapamide or any component of the formulation, thiazides, or sulfonamide-derived drugs. Anuria. Renal decompensation. Pregnancy.

Warnings and precautions

Hyponatremia, hypokalemia, hypochloremic alkalosis, hypomagnesemia can occur. Photosensitization might occur. Use in thiazide or sulfonamide allergy contraindicated. Use with caution in prediabetes or diabetes mellitus (possible change in glucose control). Gout can be precipitated in certain risk patients. Use with caution in severe hepatic or renal dysfunction. Use with caution in moderate or high cholesterol concentrations. Can cause systemic lupus erythematosus exacerbation or activation. Rash (e.g. erythematous, maculopapular, morbilliform), urticaria, pruritus, and vasculitis reported. Erythema multiforme and epidermal necrolysis rarely reported. May decrease calcium urinary excretion. Use with caution in hyperparathyroidism or thyroid disorders. Antihypertensive effect may be enhanced after sympathectomy. Use with caution in geriatric patients (increased risk of dilutional hyponatremia or of hypokalemia).



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart