Iodipamide Meglumine
- Atc Codes:V08AC
- CAS Codes:3521-84-4#606-17-7#6284-40-8
- PHARMGKB ID:3521-84-4#606-17-7#6284-40-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Therapeutic Use
- Contraindications
- Pregnancy and Lactation Implications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
Brand Names
North America
Canada: Cholografin Meglumine; USA: Cholografin Meglumine.
Drug combinations
Iodipamide Meglumine and Diatrizoate Meglumine
Chemistry
Iodipamide Meglumine: C~20~H~14~I~6~N~2~O~6~ 2C~7~H~17~NO~5~. Mw: 1530.19. Benzoic acid, 3,3′-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2). CAS-3521-84-4; CAS-606-17-7 (iodipamide); CAS-6284-40-8 (meglumine).
Pharmacologic Category
Diagnostic Agents; Imaging Agents; Iodinated Contrast Media. Radiological/Contrast Media. (ATC-Code: V08AC).
Mechanism of action
Therapeutic use
Contrast medium for intravenous cholangiography and cholecystography.
Pregnancy and lactiation implications
Reproduction studies not conducted. In general, iodinated contrast media agents are avoided during pregnancy unless essential for diagnosis.
Unlabeled use
Contraindications
Hypersensitivity to iodipamide salts or any component of the formulation. Intrathecal procedures. Concomitant severe renal and hepatic dysfunction.
Warnings and precautions
Pre-treatment with corticosteroids (prednisone) and antihistamines (diphenhydramine) may decrease frequency/severity of allergic reactions. May exacerbate sickling in sickle cell disease. Associated with nephrotoxicity. Contraindicated in severe hepatic impairment. Caution in mild-to-moderate liver disease, hypertension, debilitated patients, pheochromocytoma, previous reaction to contrast dye or iodine-based contrast media, asthma, renal impairment or predisposed to contrast-induced nephrotoxicity (diabetes, the elderly, concomitant medications such as metformin). Never use for intrathecal administration (acute renal failure, cardiac arrest, cerebral hemorrhage, coma, death, paralysis, and seizures can occur).