Isoflurane
- Atc Codes:N01AB06
- CAS Codes:26675-46-7
- PHARMGKB ID:26675-46-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Forane, Isofluran; Bulgaria: AErrane, Isoflurane, Forane, Terrell; Cyprus: Isoflurane; Czech Republic: AErrane, Forane, Isofluran; Denmark: Forene, Isofluran; Estonia: AErrane, Forane; Finland: Forene, Isofluran; France: AErrane, Forene, Isoflurane; Germany: Forane, Isoba, Isoflo, Isofluran, Narcofluran; Greece: Forenium, Isoflurane; Hungary: AErrane, Forane; Ireland: AErrane, Forane; Italy: AErrane, Forane; Latvia: Forane, Forene; Luxembourg: AErrane, Forene; Malta: AErrane, Isoflurane; Netherlands: Forene, Isofluraan; Poland: AErrane, Forane; Portugal: Forene; Romania: AErrane, Anesteran, Forane, Isoflurane; Slovakia: Forane, Isofluran; Slovenia: Forane, Izofluran; Spain: AErrane, Forane, Isoflurano; Sweden: Forene, Isofluran; UK: Forane, Isoflurane.
North America
Canada: AErrane, Forane, Isoflurane; USA: Forane, Isoflurane.
Latin America
Argentina: Forane, Isoflurane, Isoflurano, Zuflax; Brazil: Forane, Isoforine; Mexico: Forane, Sofloran.
Asia
Japan: Escain, Forane, Isoflurane.
Drug combinations
Chemistry
Isoflurane: C~3~H~2~ClF~5~O. Mw: 184.49. (1) Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; (2) 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether. CAS-26675-46-7 (1972).
Pharmacologic Category
General Anesthetics, Miscellaneous. Inhalation Anesthetic. (ATC-Code: N01AB06).
Mechanism of action
Therapeutic use
Induction and maintenance of general anesthesia.
Pregnancy and lactiation implications
Adverse fetal effects in animal studies. There are as yet no adequate studies in pregnant women. Use caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to isoflurane or any component of the formulation. History of malignant hyperthermia.
Warnings and precautions
Cardiovascular effects (might cause decrease in blood pressure, cardiac steal, reflex tachycardia). May cause decreased hepatic, renal and splenic blood flow. Hepatitis reported (rarely). Risk of hyperkalemia (increased in pediatric patients with underlying neuromuscular disease). Possible elevation in CPK and myoglobinuria. Might increase intracranial pressure. Malignant hyperthermia (avoid use in susceptibility to malignant hyperthermia). Respiratory depression.