Isoproterenol
- Atc Codes:C01CA02#R03AB02#R03CB01
- CAS Codes:51-30-9#7683-59-2
- PHARMGKB ID:51-30-9#7683-59-2
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Isuprel; Czech Republic: Euspiran; Denmark: Erydin; Finland: Saventrine; France: Isuprel; Greece: Isuprel, Saventrine; Hungary: Isuprel; Italy: Isopre; Portugal: Isoprenalina; Spain: Aleudrina.
North America
Canada: Isoproterenol; USA: Isuprel, Isoproterenol.
Latin America
Argentina: Isoproterenol.
Asia
Japan: Stmerin D.
Drug combinations
Isoproterenol and Phenylephrine
Chemistry
Isoproterenol Hydrochloride: C~11~H~17~NO~3~ HCl. Mw: 247.72. (1) 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride; (2) 3,4-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol hydrochloride. CAS-51-30-9; CAS-7683-59-2 (isoproterenol).
Pharmacologic Category
Sympathomimetic (Adrenergic) Agents; Non-selective β-Adrenergic Agonists. β~1~/β~2~-Adrenergic Agonist. (ATC-Code: C01CA02; R03AB02; R03CB01).
Mechanism of action
Stimulates β~1~- and β~2~-receptors resulting in relaxation of bronchial, GI, and uterine smooth muscle, increased heart rate and contractility, vasodilation of peripheral vasculature.
Therapeutic use
Ventricular arrhythmias due to AV nodal block. Bradyarrhythmias hemodynamically compromised or atropine- and dopamine-resistant bradyarrhythmias. Third-degree AV block until pacemaker insertion.
Pregnancy and lactiation implications
Caution if used intravenously during pregnancy or lactation.
Unlabeled use
Pharmacologic overdrive pacing for torsade de pointes. Diagnostic aid (vasovagal syncope).
Contraindications
Hypersensitivity to sulfites or isoproterenol, any component of the formulation, or other sympathomimetic amines. Angina, pre-existing cardiac arrhythmias (ventricular). Tachycardia or AV block caused by cardiac glycoside intoxication.
Warnings and precautions
Use with caution in cardiovascular disease (including CAD, coronary insufficiency, hypertension, or degenerative heart disease), diabetics, hyperthyroidism, renal impairment, history of seizure disorder, the elderly, and/or those with history of sensitivity to sympathomimetic amines. Excessive or prolonged use may result in decreased effectiveness. Use with caution in sensitivity to sympathomimetic amines. Some formulations contain sulfites (may cause allergic-type reactions).