Isosorbide Mononitrate
- Atc Codes:C01DA14
- CAS Codes:16051-77-7
- PHARMGKB ID:16051-77-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: ISMN, Isomonat, Isosorbidmononitrat, Mono Mack, Monoket, Myocardon, Olicardin; Bulgaria: Neosorbid, Olicard; Cyprus: Chemydur, Conpin, Imdur, Monosordil; Czech Republic: Isket; Denmark: Fem-Mono, Imdur, Isodur, Isosorbidmononitrat; Estonia: Conpin, Elantan, Imdur, Isomonit, Isosor, Mono Mack, Monosan, Olicard; Finland: Imdur, Isangina, Ismexin, Ismox, Isodor, Ormox; France: Monicor; Germany: Ac Isos, Coleb-Duriles, Conpin, Corangin, Coronillen, Elan, Elantan, IS 5, Ismanton, ISMN, Ismo, Isomon, Isomonit, Isosor, Moni-Sanorania, Monit-Puren, Mono 5-Wolff, Mono Acis, Mono KSK, Mono Mack, Monobeta, Monoclair, Monolong, Mononitrat, Monopur, Motrat, Olicard, Turimonit; Greece: Dilavase, G-Dil, Imdur, Isomon; Hungary: Cardisorb, Isospan, Mono Mack, Mono Tad, Monosor, Olicard, Rangin; Ireland: Cardox, Elantan, Imdur, Isomel, Isomonit, Monomax; Italy: Duronitrin, Elan, Ismo, Isosorbide, Leicester, Monocinque, Monoket, Vasdilat; Latvia: Conpin, Elantan, Imdur, ISMN, Isomonit, Isosor, Monosan, Olicard; Lithuania: Conpin, ISMN, Imdur, Isosor, Isomonit, Monosan, Olicard, Elantan; Luxembourg: Elantan, Imdur, Ismo, Isomonit, Mono Mack; Malta: Imdur, Isosorbide Mononitrate, Monosordil, Trangina; Netherlands: Isosorbide-5-mononitraat FLX, Isosorbidemononitraat, Mono-Cedocard, Promocard; Poland: Effox, Isohexal, Isomonit, Isosor, Mono Mack, Mono Tad, Monocard, Mononit, Monosan, Olicard; Portugal: Imdur, Ismo, Monoket, Mononitrato de Isossorbida, Monopront, Orasorbil; Romania: Mononitron, Olicard; Slovakia: Imdur, Mono Mack, Monosan, Monosor, Monotab, Olicard, Sorbimon; Slovenia: Monosan, Olicard, Plodin; Spain: Cardionil-Alacan, Coronur, Dolak, Mononitrato de Isosorbida, Pertil, Uniket; Sweden: Imdur, Ismo, Isodur, Isosorbidmononitrat, Monoket; UK: Chemydur, Elantan, Imdur, Isosorbide Mononitrate, Isotard, Modisal, Monomax, Monosorb, Trangina, Xismox.
North America
Canada: Imdur, ISMN; USA: Imdur, Ismo, Isosorbide Mononitrate, Monoket.
Latin America
Argentina: Cilatron, Isosorbide 5-Mononitrato, Medocor, Monoket, Monotrin; Brazil: Cincordil, Coronar, Monocordil, Mononitrato De Isossorbida; Mexico: Elantan, Imdur, Kenbrid, Monocorat.
Asia
Japan: Airocool, Aislar, Banreel, Isomonit, Isonitoll, Itorol, Soprerole, Taisirol.
Drug combinations
Chemistry
Isosorbide Mononitrate: C~6~H~9~NO~6~. Mw: 191.14. (1) D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate; (2) 1,4:3,6-Dianhydro-D-glucitol 5-nitrate. CAS-16051-77-7.
Pharmacologic Category
Vasodilating Agents; Nitrates and Nitrites. Vasodilator. (ATC-Code: C01DA14).
Mechanism of action
Decreases preload as measured by pulmonary capillary wedge pressure and left ventricular end diastolic volume and pressure. This effect improves congestive symptoms in heart failure and improves myocardial perfusion gradient in coronary artery disease.
Therapeutic use
Long-acting metabolite of vasodilator isosorbide dinitrate used for prophylactic treatment of angina pectoris.
Pregnancy and lactiation implications
Use with caution during pregnancy and lactation.
Unlabeled use
Contraindications
Hypersensitivity to isosorbide or any component of the formulation. Hypersensitivity to organic nitrates. Concurrent use with PDE-5 inhibitors (sildenafil, tadalafil, or vardenafil). Angle-closure glaucoma (intraocular pressure may be increased). Head trauma or cerebral hemorrhage (increase intracranial pressure). Severe anemia.
Warnings and precautions
Severe hypotension can occur. Paradoxical bradycardia and increased angina pectoris can accompany hypotension. Orthostatic hypotension can also occur. Use with caution in volume depletion, hypotension, right ventricular infarctions, and in hypertrophic cardiomyopathy. Avoid concurrent use with PDE-5 inhibitors (e.g. sildenafil, tadalafil, vardenafil).