Isoxsuprine
- Atc Codes:C04AA01
- CAS Codes:579-56-6#34331-89-0#395-28-8
- PHARMGKB ID:579-56-6#34331-89-0#395-28-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Italy: Vasosuprina; Portugal: Dilum.
Latin America
Argentina: Duvadilan, Isodilan, Isotenk, Isoxsuprina, Protelium, Uterine; Brazil: Inibina; Mexico: Vadosilan.
Asia
Japan: Duvadilan.
Drug combinations
Chemistry
Isoxsuprine Hydrochloride: C~18~H~23~NO~3~ HCl. Mw: 337.84. (1) Benzenemethanol, 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride, stereoisomer; (2) p-Hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]benzyl alcohol hydrochloride; (3)(±)-(αR*)-p-Hydroxy-α-[(1S*)-1-[[(1S*)-1-methyl-2-phenoxyethyl]amino]ethyl]benzyl alcohol hydrochloride. CAS-579-56-6; CAS-34331-89-0; CAS-395-28-8 (isoxsuprine).
Pharmacologic Category
Vasodilating Agents, Miscellaneous. Vasodilator. (ATC-Code: C04AA01).
Mechanism of action
Increases muscle blood flow. Probably has direct action on vascular smooth muscle. It is believed that mechanism of action on uterus is β-adrenergic stimulation.
Therapeutic use
Treatment of peripheral vascular diseases, such as arteriosclerosis obliterans and Raynaud’s disease.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to isoxsuprine or any component of the formulation. Presence of arterial bleeding. Avoid inmediate postpartum administration.
Warnings and precautions
Rash might occur. Isoxsuprine should not be administered immediately postpartum or in presence of arterial bleeding. May cause hypotension in older adults.