Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Fastum, Ketospray, Profenid, Prontoket; Belgium: Fastum, Rofenid; Cyprus: Fastum; Bulgaria: Fastum, Ketonal, Ketoprofen, Profenid, Prontoket, Topogel; Czech Republic: Fastum, Keplat, Ketonal, Profenid, Prontoflex; Denmark: Fastum, Ketoprofen, Ketospray, Orofen, Orudis; Estonia: Begsan, Fastum, Keto, Ketonal, Profenid, Prontoflex; Finland: Keto, Ketomex, Ketorin, Orudis; France: Ketoprofene, Ketum, Profenid, Topfena, Toprec; Germany: Advel Gel, Alrheumun, Danidol, Dinalgen, Dolormin Schmerzgel mit Ketoprofen, Effekton Gel mit Ketoprofen, Gabrilen, Reparil, Romefen, Spondylon; Greece: Drastirel, Farbovil, Ketoprofen, Menaril, Oruvail; Hungary: Algoflex Gel, Fastum, Keplat, Ketospray, Profenid, Prontoket; Ireland: Fastum, Orugesic, Oruvail; Italy: Alket, Dolgosin, Euketos, Fastum, Flexen, Hiruflog, Ibifen, Isofenal, Keplat, Ketofarm, Ketoplus, Ketrofene, Ketoselect, Lasonil, Liotondol, Orudis, Steofen; Latvia: Fastum, Keto, Ketonal, Profenid, Prontoket, Spinax; Lithuania: Fastum, Keto, Ketospray, Ketonal, Prontoket, Spinax; Luxembourg: Ketoprofene, Profenid; Malta: Fastum, Profenid; Netherlands: Ketoprofen, Orudis, Oruvail, Oscorel, Rilies; Poland: Apo-Keto, Fastum, Febrofen, Keplat, Ketonal, Ketoprofen, Ketoprofenum, Ketoprom, Ketopronil, Ketores, Ketospray, Prontoket, Refastin, Ultrafastin; Portugal: Fastum, Keplat, Profenid; Romania: Fastum, Ketard, Ketomag, Ketonal, Ketoprofen, Ketoproxin, Ketospray, Profenid, Rubifen; Slovakia: Fastum, Ketonal, Ketoprofen, Ketospray; Slovenia: Ketonal, Ketoprofen, Prontoflex; Spain: Arcental, Fastum, Ketoprofeno, Orudis; Sweden: Ketoflex, Ketoprofen, Orudis, Siduro, Zon; UK: Ketocid, Ketovail, Orudis, Oruvail, Powergel.

North America

Canada: Apo-Keto, Ketoprofen; USA: Ketoprofen, Nexcede.

Latin America

Argentina: Helenil, Ketfren, Salicrem K; Brazil: Artrifenil, Artrinid, Artrosil, Ceprofen, Cetoprofeno, Flamador, Profenid; Mexico: Arthril, Ketoflex, Ketoprofeno, K-Profen, Orudis, Painsik, Profenid.


Japan: Aneol, Capisten, Epatec, Frestol, Ketok, Ketoprofen, Ketoraneal, Ketotax, Megeide, Menamin, Miltax, Mohrus, Nicool K, Olusapos, Orudis SR, Pappen K, Patell, Pestec, Raynanon, Rheila, Riferon, Romal, Sector, Sitestep, Touchron.

Drug combinations

Ketoprofen and Acetaminophen

Ketoprofen and Omeprazole


Ketoprofen: C~16~H~14~O~3~. Mw: 254.28. (1) Benzeneacetic acid, 3-benzoyl-a-methyl-, (±)-; (2)(±)-m-Benzoylhydratropic acid. CAS-22071-15-4 (1972).

Pharmacologic Category

Analgesics and Antipyretics; Other Nonsteroidal Anti-inflammatory Agents. (ATC-Code: M01AE03; M02AA10).

Mechanism of action

Inhibits prostaglandin synthesis by decreasing activity of enzyme cyclooxygenase, which results in decreased formation of prostaglandin precursors. Has antipyretic, analgesic, and anti-inflammatory properties.

Therapeutic use

Acute and long-term treatment of rheumatoid arthritis and osteoarthritis. Primary dysmenorrhea. Mild-to-moderate pain.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to ketoprofen, aspirin, other NSAIDs, or any component of the formulation. Perioperative pain in setting of CABG surgery.

Warnings and precautions

Anaphylactoid reactions might occur (do not use in patients who experience asthma, bronchospasm, rhinitis, or urticaria with NSAID or aspirin therapy). Platelet adhesion and aggregation may be decreased. May prolong bleeding time. Anemia might occur. Increased risk of adverse cardiovascular thrombotic events, including MI, stroke, and new onset or worsening of pre-existing hypertension (use caution with fluid retention, heart failure, or hypertension). NSAIDs may increase risk of GI irritation, inflammation, ulceration, bleeding, and perforation. Use caution with history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients. May cause serious skin adverse events including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Do not administer to patients with aspirin-sensitive asthma (severe bronchospasm might occur). Use caution in other forms of asthma. Risk of MI and stroke may be increased with use following CABG surgery. Use with caution in decreased hepatic function. Dose-dependent decreases in prostaglandin synthesis may result from NSAID use, reducing renal blood flow which may cause renal decompensation. Patients with impaired renal function, dehydration, heart failure, liver dysfunction, those taking diuretics, and ACEIs, and the elderly are at greater risk of renal toxicity. Not recommended for use in advanced renal disease. Long-term NSAID use may result in renal papillary necrosis. The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity). Withhold for at least 4-6 half-lives prior to surgical or dental procedures.



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