Ketotifen
- Atc Codes:R06AX17#S01GX08
- CAS Codes:34580-14-8#34580-13-7
- PHARMGKB ID:34580-14-8#34580-13-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Ketotisan, Zaditen; Belgium: Ketotifen, Zaditen; Bulgaria: Ketotifen, Zaditen; Cyprus: Licoften, Tenerel, Xidanef, Zaditen; Czech Republic: Ketof, Ketotifen, Zaditen; Denmark: Zaditen; Finland: Zaditen; France: Zaditen; Germany: Ketitab, Ketitrop, Ketof, Ketofex, Ketotifen, Pädiatifen, Zaditen; Greece: Cleroptic, Dovidin, Eucycline, Fental, Frenasma, Isocare, K-Drops, Kathricol, Ketotifen, Meni-Drops, Noxtor, Orpidix, Pellexeme, Zaditen, Zethrinal; Hungary: Zaditen; Ireland: Zaditen; Italy: Bentifen, Brunistill, Chetofen, Chetotifene, Ketoftil, Sosefen, Zaditen; Latvia: Ketotifen; Lithuania: Ketotifen, Zaditen; Luxembourg: Ketof, Ketotifen, Zaditen; Malta: Ketoftil, Zaditen; Netherlands: Ketotifen, Zaditen; Poland: Ketof, Ketotifen, Pozitan, Zaditen; Portugal: Bentifen, Cipanfeno, Zaditen; Romania: Frenasma, Ketof, Ketotifen, Zaditen; Slovakia: Denerel, Ketotifen, Zaditen; Slovenia: Zaditen; Spain: Zaditen, Zasten; Sweden: Bentifen, Zaditen; UK: Zaditen.
North America
Canada: Ketotifen, Zaditen, Zaditor; USA: Alaway, Ketotifen, Zaditor.
Latin America
Argentina: Antilerg, Bilozen, Farmoftal, Hyalcrom NF, Ketocev, Respimex, Zaditen; Brazil: Asdron, Asmalergin, Asmax, Asmen, Asmifen, Asmofen, Biatós, Fumarato de Cetotifeno, Zaditen; Mexico: Asmaral K, Biotifen, Cantel, Kasmal, Kedrop, Keraffler, Ketotifeno, Nemodine, Nomotec, Osaten, Pretifen, Saluket H1, Ventisol, Zaditen.
Asia
Japan: Allegy S, Anatifen, Benanza, Benapy, Cratifen, Dezuwart, Drakern, Electer, Fumarton, Fumarufen, Fusachol, Ketoten, Ketotifen, Ketotifen fumarate, Ketotilon, Magotiphen, Mellabon, Nichicard, Sadifen, Salatine, Saldimen, Sekiton, Supdel, Xeblen, Zaditen, Zaditoma, Zaltifen, Zatotiten, Zikilion.
Drug combinations
Chemistry
Ketotifen Fumarate: C~19~H~19~NOS C~4~H~4~O~4~. Mw: 425.50. (1) 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1); (2) 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one fumarate (1:1). CAS-34580-14-8; CAS-34580-13-7 (ketotifen)(1979).
Pharmacologic Category
EENT Preparations; Antiallergic Agents; Second Generation Histamine H~1~ Antagonist. Mast Cell Stabilizer. (ATC-Code: R06AX17; S01GX08).
Mechanism of action
Exhibits noncompetitive H~1~-receptor antagonist and mast cell stabilizer properties. Efficacy in conjunctivitis and asthma probably results from combination of anti-inflammatory and antihistaminergic actions, including interference with chemokine-induced migration of eosinophils into inflamed conjunctiva and airways, inhibition of airway hyper-reactivity due to platelet aggregating factor (PAF), antagonism of leukotriene-induced bronchoconstriction.
Therapeutic use
Temporary prevention of eye itching due to allergic conjunctivitis. Chronic treatment of pediatric patients ≥6 months of age with mild, atopic asthma.
Pregnancy and lactiation implications
Caution if used during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to ketotifen or any component of the formulation.
Warnings and precautions
May cause drowsiness. Rare cases of thrombocytopenia reported with concurrent use of oral ketotifen and oral antidiabetic agents. Oral ketotifen should not be used to treat acute asthma attacks. Ophthalmic solution not intended for treatment of contact lens-related irritation. Syrup products may contain benzoate compounds. Possible delayed clinical response.