Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Aldurazyme; Belgium: Aldurazyme; Bulgaria: Aldurazyme; Cyprus: Aldurazyme; Czech Republic: Aldurazyme; Denmark: Aldurazyme; Estonia: Aldurazyme; Finland: Aldurazyme; France: Aldurazyme; Germany: Aldurazyme; Greece: Aldurazyme; Hungary: Aldurazyme; Ireland: Aldurazyme; Italy: Aldurazyme; Latvia: Aldurazyme; Lithuania: Aldurazyme; Luxembourg: Aldurazyme; Malta: Aldurazyme; Netherlands: Aldurazyme; Poland: Aldurazyme; Portugal: Aldurazyme; Romania: Aldurazyme; Slovakia: Aldurazyme; Slovenia: Aldurazyme; Spain: Aldurazyme; Sweden: Aldurazyme; UK: Aldurazyme.

North America

Canada: Aldurazyme; USA: Aldurazyme.


Japan: Aldurazyme.

Drug combinations


Laronidase: C~3567~H~5645~N~921~O~1261~S~12~P~4~. Mw: 82067.15. Iduronidase, α-L-[8-histidine] (human). CAS-210589-09-6 (2000).

Pharmacologic Category

Enzymes. (ATC-Code: A16AB05).

Mechanism of action

Breaks down endogenous glycosaminoglycans within lysosomes.

Therapeutic use

Treatment of Hurler and Hurler-Scheie forms of mucopolysaccharidosis I (MPS I). Treatment of Scheie form of MPS I in moderate-to-severe symptoms.

Pregnancy and lactiation implications

Unlabeled use


None known to date.

Warnings and precautions

Anaphylactic reactions observed during infusion. Patients with compromised respiratory function or acute respiratory disease may be at increased risk for acute exacerbation of respiratory symptoms due to infusion reaction. In anaphylaxis, caution should be used if epinephrine is being considered (many patients with MPS I have pre-existing heart disease). Not indicated for CNS manifestations of Scheie form of MPS I disorder. Prepared infusions contain human albumin.



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