Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Refludan; Belgium: Refludan; Bulgaria: Refludan; Cyprus: Refludan; Czech Republic: Refludan; Denmark: Refludan; Estonia: Refludan; Finland: Refludan; France: Refludan; Germany: Refludan; Greece: Refludan; Hungary: Refludan; Ireland: Refludan; Italy: Refludan; Latvia: Refludan; Lithuania: Refludan; Luxembourg: Refludan; Malta: Refludan; Netherlands: Refludan; Poland: Refludan; Portugal: Refludan; Romania: Refludan; Slovakia: Refludan; Slovenia: Refludan; Spain: Refludin; Sweden: Refludan; UK: Refludan.

North America

Canada: Refludan; USA: Refludan (d).

Drug combinations


Lepirudin: C~287~H~440~N~80~O~111~S~6~. Mw: 6979.42. 1-L-Leucine-2-L-threonine-63-desulfohirudin (Hirudo medicinalis isoform HV1). CAS-138068-37-8.

Pharmacologic Category

Anticoagulants; Direct Thrombin Inhibitors. (ATC-Code: B01AE02).

Mechanism of action

Specific direct inhibitor of thrombin.

Therapeutic use

Anticoagulation in heparin-induced thrombocytopenia and associated thromboembolic disease.

Pregnancy and lactiation implications

Unlabeled use

Investigational: Prevention or reduction of ischemic complications associated with unstable angina.


Hypersensitivity to hirudins or any component of the formulation.

Warnings and precautions

Anaphylaxis and hypersensitivity reactions reported. Bleeding common. Use with caution in cirrhosis, or in renal impairment. Administer cautiously after a thrombolytic episode (risk of intracranial bleeding). Allergic reactions common with concomitant administration of streptokinase. Contraindicated in recent stroke.



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