Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Femara, Letrofam, Letrozol; Belgium: Femara; Bulgaria: Femara, Letrofemin, Letrosander; Cyprus: Femara; Czech Republic: Aletro, Arofek, Attozette, Brenea, Britagal, Britapons, Clarzole, Dracenax, Etruzil, Femara, Femtozette, Helzette, Lerana, Lestara, Letroger, Letrozette, Letrozol, Letrozole, Letrozolum, Loosyn, Oncozol, Oralet, Trozara, Trozel; Denmark: Femar, Femara, Letrozol; Estonia: Femara, Femtozette, Letroger, Letrozol, Letrozole, Mionic, Picozette, Trozel; Finland: Femar, Femara, Letrolan; France: Femara; Germany: Femar, Femara, Femtozone, Letrobeta, Letrostad, Letrozac, Letrozol, Letrozomic, Letrozonam, Letrozoter, Letrozozett, Mionic, Petazone, Picozone, Ribotrozol, Terazone, Yoktozone; Greece: Femaplex, Femara, Leoncon, Letropen, Letrozin, Letrozol, Letrozole, Levinox, Linol, Mimor, Religan, Stefaplex; Hungary: Femara; Ireland: Eirfem, Femara, Letrozole; Italy: Femara; Latvia: Letrozole, Lithuania: Femara, Femtozone, Letrozol, Letrozole, Mionic, Picozone, Trozel; Luxembourg: Femara; Malta: Letrozole, Femara; Netherlands: Etruzil, Femara, Letaris, Letrozin, Letrozol; Poland: Aromek, Attozone, Etruzil, Femara, Femtozone, Lametta, Letrozol, Letrozole, Letrozone, Lostar, Picozone; Portugal: Femara, Letrozol; Romania: Estronal, Etruzil, Falvax, Femara, Letralan, Letrozol, Letrozole, Loosyn, Trozara, Trozel, Zotrol; Slovakia: Aletro, Brenea, Etruzil, Femara, Femtozone, Letroger, Letromedac, Letrozac, Letrozol, Letrozole, Letrozolum, Lidiozol, Loosyn, Oralet, Trozel; Slovenia: Femara, Femtozone, Letrozol, Picozone; Spain: Femara, Letrozol, Loxifan; Sweden: Femar, Letralan, Letrozol; UK: Femara.

North America

Canada: Femara; USA: Femara, Letrozole.

Latin America

Argentina: Cendalon, Fecinole, Femara, Kebirzol, Letrozol; Brazil: Femara; Mexico: Femara.


Japan: Femara.

Drug combinations


Letrozole: C~17~H~11~N~5~. Mw: 285.30. (1) Benzonitrile, 4,4′-(1H-1,2,4-triazol-1-ylmethylene)bis-; (2) 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile. CAS-112809-51-5. 20267 (1993).

Pharmacologic Category

Antineoplastic Agents; Endocrine Therapy; Aromatase Inhibitor. (ATC-Code: L02BG04).

Mechanism of action

Nonsteroidal competitive inhibitor of the aromatase enzyme. Inhibits the enzyme and reduces estrogen levels.

Therapeutic use

For use in postmenopausal women in adjuvant treatment of hormone receptor-positive early breast cancer, extended adjuvant treatment of early breast cancer after 5 years of tamoxifen, advanced breast cancer with disease progression following antiestrogen therapy, hormone receptor-positive or hormone receptor unknown, locally-advanced, or metastatic breast cancer.

Pregnancy and lactiation implications

May cause fetal harm. Embryotoxic, fetotoxic, and teratogenic in animals. Use with caution during lactation.

Unlabeled use

Treatment of ovarian (epithelial) cancer, endometrial cancer.


Hypersensitivity to letrozole or any component of the formulation. Women of premenopausal endocrine status. Pregnancy.

Warnings and precautions

Hazardous agent. May cause dizziness, fatigue, and somnolence. May cause decreases in bone mineral density. May increase total serum cholesterol. Use with caution in hepatic impairment. Risk of osteoporosis.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Email: genomicmedicine@wagem.org
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart