In patients with past or present psychoses, deterioration or recurrence of symptoms is possible (must be considered very carefully in severe disorders of arterial circulation in periphery and heart (coronary failure)). High blood pressure, MI, convulsive fits and stroke (known symptoms of postpartum cerebral angiopathy) observed in rare cases in association with use of ergot-derived dopamine agonists as lactation inhibitor in puerperal period. Although no causal association between treatment and these events -which also occur spontaneously in puerperal period- has been confirmed, treatment should be discontinued immediately, as a precaution, on the occurrence of high blood pressure, persistent headache or other signs of disturbance of CNS in women taking lisuride for ablactation. Before starting treatment of hyperprolactinemia with lusiride, cause of disorder must be clarified (e.g. medicines, hypothyroidism). Of particular importance is the question of whether there is an invasive, large adenoma of the pituitary gland. In the case of visual field defects or if the sella is significantly enlarged, either surgery or lisuride treatment alone can be applied. Pathological gambling, increased libido and hypersexuality reported in patients treated with dopamine agonists for Parkinson’s disease, including lisuride. Persons with impaired renal function, especially dialysis patients, are particularly sensitive to dopamine agonists. Use with caution in severe disturbances of liver function (lisuride is almost completely metabolized in liver). If pregnancy occurs in women with pituitary adenoma (prolactinoma), signs of renewed tumor growth (severe and sustained headaches, disturbed vision), must be very closely observed by adequate diagnostic measures. Development of cardiac fibrosis, pulmonary fibrosis, pleural fibrosis, pleural effusion or retroperitoneal fibrosis observed in isolated cases after long-term use of ergot-type dopamine agonists, including lisuride. Shortness of breath, persistent urge to cough or disturbances of kidney function occurring under treatment with lisuride must be clarified by appropriate diagnostic procedures; if necessary lisuride should be withdrawn.