Disinhibiting effects may be manifested in various ways. Suicide may be precipitated in patients who are depressed and who exhibit aggressive behavior towards self and others. Extreme caution should therefore be used in prescribing benzodiazepines in personality disorders. In general, dependence potential of benzodiazepines is low but increases when high doses are attained, especially when given over long periods and particularly in history of alcoholism or drug abuse. However, withdrawal symptoms occur even with normal therapeutic doses given for short periods of time. Withdrawal from benzodiazepines may be associated with physiological and psychological symptoms of withdrawal including depression, anxiety, tension, restlessness, confusion, irritability and headaches. Rebound insomnia may also occur. May be accompanied by other reactions such as changes in mood, anxiety, sleep disturbances and restlessness. Use with caution in chronic pulmonary insufficiency, cerebrovascular disease and chronic renal or hepatic impairment. Benzodiazepines should be used to treat insomnia only when it is severe, disabling or subjecting individual to extreme distress.