Benzodiazepines associated with anterograde amnesia. Might cause CNS depression. Paradoxical reactions, including hyperactive or aggressive behavior, reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Potential for drug dependency exists. Tolerance, psychological and physical dependence may occur with prolonged use. Use with caution in hepatic impairment. Might worsen hepatic encephalopathy. Use with caution in impaired gag reflux. Use caution in depression, particularly if suicidal risk may be present. Not recommended for use in primary depressive or psychotic disorders. Use with caution in renal impairment. Use with caution in respiratory disease, including COPD or sleep apnea. Benzodiazepines may cause significant respiratory depression. Effects with other sedative drugs or ethanol might be potentiated. Use with caution in debilitated patients. Benzodiazepines associated with falls and traumatic injury. Some products may contain benzyl alcohol («gasping syndrome» in neonates). Parenteral formulation contains polyethylene glycol. Does not have analgesic, antidepressant, or antipsychotic properties. Rebound or withdrawal symptoms might occur following abrupt discontinuation or large decreases in dose. Flumazenil may cause acute withdrawal in patients receiving long-term benzodiazepine therapy.