Magnesium Chloride
- Atc Codes:A12CC01#B05XA11
- CAS Codes:7791-18-6#7786-30-3
- PHARMGKB ID:7791-18-6#7786-30-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Poland: Slow-Mag.
North America
USA: Chloromag, Mag 64, Mag Delay, Mag-SR, Slow-Mag.
Drug combinations
Magnesium Chloride: Arginine; Calcium Citrate; Calcium Chloride; Calcium Gluconate; Calcium Lactate; Ginseng; Sodium Acetate; Sodium Bicarbonate; Sodium Chloride; Sodium Lactate; Sodium Phosphate
Chemistry
Magnesium Chloride: MgCl~2~ 6H~2~O. Mw: 203.30. Magnesium chloride hexahydrate. CAS-7791-18-6; CAS-7786-30-3 (anhydrous).
Pharmacologic Category
Replacement Preparations; Electrolyte Solutions. Oral Electrolyte Supplement. Parenteral Electrolyte Supplement. Nutritional Supplements. Magnesium Salt. (ATC-Code: A12CC01; B05XA11).
Mechanism of action
Cofactor in many enzymatic reactions in the body involving protein synthesis and carbohydrate metabolism. Actions on lipoprotein lipase found to be important in reducing serum cholesterol and on sodium/potassium ATPase in promoting polarization (e.g. neuromuscular functioning).
Therapeutic use
Correction or prevention of hypomagnesemia. Dietary supplement.
Pregnancy and lactiation implications
Reproduction studies not conducted. Magnesium crosses placenta. Magnesium found in breast milk.
Unlabeled use
Contraindications
Hypersensitivity to any component of the formulation. Renal impairment. Myocardial disease. Coma.
Warnings and precautions
Use with extreme caution in myasthenia gravis or other neuromuscular disease. Use with caution in renal impairment (accumulation might lead to magnesium intoxication). Solutions may contain aluminum (toxic levels might occur following prolonged administration in premature neonates or in renal impairment). Electrolyte abnormalities (hypokalemia or hypocalcemia) possible along with magnesium deficit. Magnesium toxicity can lead to fatal cardiovascular arrest and/or respiratory paralysis.