Manganese
- Atc Codes:A12C#B05XA
- CAS Codes:13446-34-9#7773-01-5#10034-96-5#7785-87-7#6485-39-8
- PHARMGKB ID:13446-34-9#7773-01-5#10034-96-5#7785-87-7#6485-39-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Mangimin.
Asia
Japan: Bothdel.
Drug combinations
Manganese: Ascorbic Acid (Vitamin C); Biotin (Vitamin B~7~); Calcium Citrate; Cyanocobalamin (Vitamin B~12~); Dexpanthenol; Ferrous Fumarate; Ferrous Sulfate; Fluoride; Folic Acid (Vitamin B~9~); Ginseng; L-Lysine; Niacin (Vitamin B~3~); Niacinamide; Phytonadione (Vitamin K~1~); Pyridoxine (Vitamin B~6~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~)
Chemistry
Manganese Chloride: MnCl~2~ 4H~2~O. Mw: 197.91. (1) Manganese chloride tetrahydrate; (2) Manganese^2+^ chloride tetrahydrate. CAS-13446-34-9; CAS-7773-01-5 (anhydrous).
Manganese Sulfate: MnSO~4~ H~2~O. Mw: 169.02. Sulfuric acid, manganese^2+^ salt (1:1) monohydrate. CAS-10034-96-5; CAS-7785-87-7 (anhydrous); CAS-6485-39-8.
Pharmacologic Category
Replacement Preparations; Electrolyte Solutions. Nutritional Supplements. Parenteral Trace Element. (ATC-Code: A12C; B05XA).
Mechanism of action
Cofactor which stimulates synthesis of cholesterol and fatty acids in liver, and influences mucopolysaccharide synthesis.
Therapeutic use
Trace element added to total parenteral nutrition solution to prevent manganese deficiency. Orally as dietary supplement.
Pregnancy and lactiation implications
Normal concentrations of manganese found in human milk are generally lower than cow’s milk or those found in food sources. Compatible with breast-feeding.
Unlabeled use
Contraindications
High manganese levels. Severe liver dysfunction or cholestasis (conjugated bilirubin >2 mg/dL) due to reduced biliary excretion.
Warnings and precautions
Use with caution in hepatic impairment. Manganese chloride solution for injection contains aluminum (use caution with impaired renal function and in premature infants).